Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ. Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder. In International Congress 2001: "Severe Debilitating diseases". Abstract Book. Johannesburg (JAR): Medunsa University (JAR), 2001, p. 89. sv. 1.

Basic information

Original name

Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder

Authors

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ

Edition

Johannesburg (JAR), International Congress 2001: "Severe Debilitating diseases". Abstract Book. p. 89-89, sv. 1, 2001

Publisher

Medunsa University (JAR)

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

South Africa

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/01:00004764

Organization unit

Faculty of Medicine

Keywords in English

Pharmacogenetics; genetic polymorphism; cytochrome P 450 2D6; depressive disorder; adverse effects;

Tags

adverse effects, cytochrome P 450 2D6, depressive disorder, genetic polymorphism, Pharmacogenetics

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Abstract

V originále

Adverese effects of the long-term therapy with SSRI antidepressants including sexual disorders may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors.

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Links

NF6159, research and development project

Name: Dynamika fenotypu CYP 2D6 u pacientů léčených paroxetinem ve vztahu ke klinickým korelátům. Investor: Ministry of Health of the CR, Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates