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@inproceedings{378866, author = {Ševčíková, Sabina and Zahradníčková, Eva and Souček, Karel and Šmarda, Jan}, address = {Frederick, Maryland, USA}, booktitle = {The Seventeenth Annual Meeting on Oncogene}, keywords = {Myb; Fos; Jun; differentiation}, language = {eng}, location = {Frederick, Maryland, USA}, pages = {171-171}, publisher = {Foundation for Advanced Cancer Studies, Inc.}, title = {v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts}, year = {2001} }
TY - JOUR ID - 378866 AU - Ševčíková, Sabina - Zahradníčková, Eva - Souček, Karel - Šmarda, Jan PY - 2001 TI - v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts PB - Foundation for Advanced Cancer Studies, Inc. CY - Frederick, Maryland, USA KW - Myb KW - Fos KW - Jun KW - differentiation N2 - The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells into mature blood cells. Proto-oncogenes of the fos/jun family are considered to be positive regulators of myeloid differentiation. Enforced c-fos and c-jun expression in certain myeloid leukemia cell lines results in increased propensity to differentiate. The line of v-Myb-transformed chicken monoblasts (BM2) can be induced to differentiate phorbol esters. Differentiation-promoting effects of 12-O-tetradecanoyl phorbol 13-acetate (TPA) on BM2 cells is carried though activation of protein kinase C followed by changes of activities of differentiation and proliferation regulators, including AP-1. To gain further insights into the role of fos/jun in leukemogenicity, BM2vJUN and BM2vFOS cell lines, which inducibly express v-jun and v-fos, respectively, were established. We found that either v-fos- or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. They decrease ability to reduce NBT and increase expression of differentiation-specific markers as Mo-1 and MEP-17. This suggests that oncogenic forms of Jun and Fos proteins can further enforce v-Myb transformation. ER -
ŠEVČÍKOVÁ, Sabina, Eva ZAHRADNÍČKOVÁ, Karel SOUČEK a Jan ŠMARDA. v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts. In \textit{The Seventeenth Annual Meeting on Oncogene}. Frederick, Maryland, USA: Foundation for Advanced Cancer Studies, Inc., 2001, s.~171.
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