Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in
multifactorial diseases.

J 2001

Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ, Vladimír VAŠKŮ, Svatava TSCHÖPLOVÁ, Andrea STEJSKALOVÁ et. al.

Základní údaje

Originální název

Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.

Autoři

VAŠKŮ, Anna (203 Česká republika, garant), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika), Vladimír VAŠKŮ (203 Česká republika), Svatava TSCHÖPLOVÁ (203 Česká republika) a Andrea STEJSKALOVÁ (203 Česká republika)

Vydání

Pathophysiology, Amsterdam (Netherlande), Elsevier, 2001, 0928-4680

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/01:00005187

Organizační jednotka

Lékařská fakulta

Změněno: 24. 4. 2003 10:13, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

The aim of the study is to compare results of three association (case-control) studies in three multifactorial disorders (essential hypertension, atopic diseases and psoriasis) with two polymorphisms of angiotensinogen gene (M235T and A(-6)G AGT). The diseases were chosen for their multigenic base and different immunological characteristic (Th1, Th2 and Thps) and angiotensinogen gene for its pleiotropic functional effects in general adaptive reactions. In all (control as well as case) groups, tight linkage disequilibrium between the polymorphisms was found. The strength of linkage (%) differed among the group. The direction of the linkage is identical in all groups (T is combined with A, M is combined with G). In hypertensive-normotensive study, only Hardy-Weinberg disequilibria were found, especially in men. No case-control differences were found for either single alleles or for allelic concurrence of both polymorphisms. In atopy-control study, marginal case-control differences in single allele distribution of both polymorphisms were found, but only in women. In psoriasis-control study, the only significant case-control difference was found when genotypes MTAA and MTGG were present in 2/136 psoriatic patients vs. 20/142 control subjects (OR 0.1, 95% confidence interval 0.02-0.42, P=0.00015). The frequent polymorphisms in pleiotropic genes can form different formulae of genotype distribution in different multigenic diseases according to their contribution to the onset and/or progression of the disease in some evolutionary consequences.

Návaznosti

GA306/93/2192, projekt VaV

Název: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Grantová agentura ČR, Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense

GA306/96/0099, projekt VaV

Název: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Grantová agentura ČR, Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ, Vladimír VAŠKŮ, Svatava TSCHÖPLOVÁ a Andrea STEJSKALOVÁ. Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. Pathophysiology. Amsterdam (Netherlande): Elsevier, 2001, roč. 2001, č. 8, s. 113-118. ISSN 0928-4680.

@article{385131,
   author = {Vašků, Anna and Izakovičová Hollá, Lydie and Vašků, Vladimír and Tschöplová, Svatava and Stejskalová, Andrea},
   article_location = {Amsterdam (Netherlande)},
   article_number = {8},
   language = {eng},
   issn = {0928-4680},
   journal = {Pathophysiology},
   title = {Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.},
   volume = {2001},
   year = {2001}
}

TY  - JOUR
ID  - 385131
AU  - Vašků, Anna - Izakovičová Hollá, Lydie - Vašků, Vladimír - Tschöplová, Svatava - Stejskalová, Andrea
PY  - 2001
TI  - Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.
JF  - Pathophysiology
VL  - 2001
IS  - 8
SP  - 113
EP  - 113
PB  - Elsevier
SN  - 09284680
N2  - The aim of the study is to compare results of three association (case-control) studies in three multifactorial disorders (essential hypertension, atopic diseases and psoriasis) with two polymorphisms of angiotensinogen gene (M235T and A(-6)G AGT). The diseases were chosen for their multigenic base and different immunological characteristic (Th1, Th2 and Thps) and angiotensinogen gene for its pleiotropic functional effects in general adaptive reactions. In all (control as well as case) groups, tight linkage disequilibrium between the polymorphisms was found. The strength of linkage (%) differed among the group. The direction of the linkage is identical in all groups (T is combined with A, M is combined with G). In hypertensive-normotensive study, only Hardy-Weinberg disequilibria were found, especially in men. No case-control differences were found for either single alleles or for allelic concurrence of both polymorphisms. In atopy-control study, marginal case-control differences in single allele distribution of both polymorphisms were found, but only in women. In psoriasis-control study, the only significant case-control difference was found when genotypes MTAA and MTGG were present in 2/136 psoriatic patients vs. 20/142 control subjects (OR 0.1, 95% confidence interval 0.02-0.42, P=0.00015). The frequent polymorphisms in pleiotropic genes can form different formulae of genotype distribution in different multigenic diseases according to their contribution to the onset and/or progression of the disease in some evolutionary consequences.
ER  -

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ, Vladimír VAŠKŮ, Svatava TSCHÖPLOVÁ a Andrea STEJSKALOVÁ. Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. \textit{Pathophysiology}. Amsterdam (Netherlande): Elsevier, 2001, roč.~2001, č.~8, s.~113-118. ISSN~0928-4680.

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