MOHAMED, Walid Fathalla and Pavel PAZDERA. The reactivity of N3-Aryl-N1-(2-phenylquinazolin-4-yl)thioureas. In Sborník príspevkov 53. zjazd Chemických spoločností. 1st ed. Banká Bystrica: FPV Univerzita Mateja Bela v Banskej Bystrici, 2001, p. 279-280. 1. ISBN 80-89029-22-1.
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Basic information
Original name The reactivity of N3-Aryl-N1-(2-phenylquinazolin-4-yl)thioureas
Authors MOHAMED, Walid Fathalla and Pavel PAZDERA.
Edition 1. vyd. Banká Bystrica, Sborník príspevkov 53. zjazd Chemických spoločností, p. 279-280, 1. 2001.
Publisher FPV Univerzita Mateja Bela v Banskej Bystrici
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10401 Organic chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/01:00005235
Organization unit Faculty of Science
ISBN 80-89029-22-1
Keywords in English Quinazolines; thioureas; guanidines
Tags guanidines, quinazolines, thioureas
Changed by Changed by: doc. RNDr. Pavel Pazdera, CSc., učo 2276. Changed: 8/1/2002 16:29.
Abstract
The model compound N3-aryl-N1-(2-phenyl-3,4-dihydroquinazolin-4-yl)thiourea 1 was synthesized in a Domino reaction of N2-(2-cyanophenyl)-N1-thioxomethylidenebenzene-1-carboximidamide with anilines. This compound reacts with alkyl halides, phenacyl bromides, chloroacetic acid derivatives, amines, amines in the presence of H2O2, amines in the presence of CH2O (under Mannich reaction conditions) and acyl halides to give a variety of compounds. The structure of these products together with the reason for there formation proved by quantum computational studies will be reported in this contribution. Compounds were identified by FTIR, 1H NMR, 13C NMR, X-ray, mass spectroscopy and by the ab initio computational.
Links
GA203/01/1333, research and development projectName: Chalkogenorganické sloučeniny - příprava, transformace a strukturní studie
Investor: Czech Science Foundation, Chalcogen organic compounds - synthesis, transformation and structure elucidation
MSM 143100011, plan (intention)Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů
Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles
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