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@inproceedings{388651, author = {Fojtová, Miloslava and Fulnečková, Jana and Fajkus, Jiří and Kovařík, Aleš}, address = {New York}, booktitle = {Journal of Biomolecular Structure and Dynamics}, keywords = {cadmium-induced apoptosis; tobacco}, language = {eng}, location = {New York}, pages = {963-963}, publisher = {Adenine Press}, title = {Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells}, year = {2001} }
TY - JOUR ID - 388651 AU - Fojtová, Miloslava - Fulnečková, Jana - Fajkus, Jiří - Kovařík, Aleš PY - 2001 TI - Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells PB - Adenine Press CY - New York KW - cadmium-induced apoptosis KW - tobacco N2 - To monitor apoptotic changes, we followed several parameters including cell viability, DNA integrity and telomerase activity.Preapoptotic phase has been achieved by exposure of cells to 50mM cadmium for 3 days.At that time the cell culture retains more than 95% viability although the majority of DNA is fragmented into 50-200 kb.Integrity of DNA is reestablished within two days after cadmium removal suggesting that an efficient DNA repair process has occurred.In parallel, a significant increase of telomerase activity in cell extracts is observed.The data suggest an involvement of telomerase in plant chromosome healing in response to damage caused by genotoxic agents. ER -
FOJTOVÁ, Miloslava, Jana FULNEČKOVÁ, Jiří FAJKUS a Aleš KOVAŘÍK. Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells. In \textit{Journal of Biomolecular Structure and Dynamics}. New York: Adenine Press, 2001, s.~963. ISSN~0739-1102.
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