Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy

NAVRÁTILOVÁ, Hana. Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy. Chirality. USA: Willey-Liss, 2001, vol. 13, No 10, p. 731-735. ISSN 0899-0042.

Basic information

• Original name: Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy
• Authors: NAVRÁTILOVÁ, Hana.
• Edition: Chirality, USA, Willey-Liss, 2001, 0899-0042.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10401 Organic chemistry
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.554
• RIV identification code: RIV/00216224:14330/01:00005424
• Organization unit: Faculty of Informatics
• UT WoS: 000172005600024
• Keywords in English: spectral non-equivalence; piperidines; NMR; paroxetine
• Tags: NMR, paroxetine, piperidines, spectral non-equivalence

Abstract

S-Mosher acid induced chemical-shift non-equivalence in NMR spectra of chiral trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines. The magnitude of Dd in 1H and 19F NMR spectra varied with the substituent at position 3 of the piperidine ring. The magnitudes Dd observed for certain protons and for the fluorine in the 4-fluorophenyl group were sufficiently large to allow determination of enantiomeric composition.

Links

• MSM 143100011, plan (intention): Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles