Detailed Information on Publication Record
2001
Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy
NAVRÁTILOVÁ, HanaBasic information
Original name
Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy
Authors
NAVRÁTILOVÁ, Hana
Edition
Magnetic Resonance in Chemistry, Great Britain, Willey and Sons, Ltd. 2001, 0749-1581
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10401 Organic chemistry
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.895
RIV identification code
RIV/00216224:14330/01:00005425
Organization unit
Faculty of Informatics
Keywords in English
NMR; 13C satellites; chemical-shift anisochrony; piperidines; paroxetine;
Změněno: 23/5/2002 15:02, RNDr. JUDr. Vladimír Šmíd, CSc.
Abstract
V originále
The chemical shift anisochrony of the fluorine signal for the enantiomerically enriched (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine was induced in the presence of S-Mosher acid and its magnitude varied with the enantiomeric purity of 1a. Very low quantities of an enantiomeric impurity 1b, ranging typically from 0.2 to 1%, were evaluated by comparing peak areas of 1b with those of 13C satellite signals that were deconvoluted using an automatic Lorentzian line fitting.
Links
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