NAVRÁTILOVÁ, Hana. Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy. Magnetic Resonance in Chemistry. Great Britain: Willey and Sons, Ltd., vol. 39, No 11, p. 727-730. ISSN 0749-1581. 2001.
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Basic information
Original name Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy
Authors NAVRÁTILOVÁ, Hana.
Edition Magnetic Resonance in Chemistry, Great Britain, Willey and Sons, Ltd. 2001, 0749-1581.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.895
RIV identification code RIV/00216224:14330/01:00005425
Organization unit Faculty of Informatics
Keywords in English NMR; 13C satellites; chemical-shift anisochrony; piperidines; paroxetine;
Tags 13C satellites, chemical-shift anisochrony, NMR, paroxetine, piperidines
Changed by Changed by: RNDr. JUDr. Vladimír Šmíd, CSc., učo 1084. Changed: 23/5/2002 15:02.
Abstract
The chemical shift anisochrony of the fluorine signal for the enantiomerically enriched (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine was induced in the presence of S-Mosher acid and its magnitude varied with the enantiomeric purity of 1a. Very low quantities of an enantiomeric impurity 1b, ranging typically from 0.2 to 1%, were evaluated by comparing peak areas of 1b with those of 13C satellite signals that were deconvoluted using an automatic Lorentzian line fitting.
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MSM 143100011, plan (intention)Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů
Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles
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