Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ and Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. Genes Immun. United Kingdom: Nature Publishing Group, 2002, vol. 3, No 5, p. 292-294. ISSN 1466-4879.

Basic information

• Original name: Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers
• Authors: IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Dana BUČKOVÁ (203 Czech Republic), Antonín FASSMANN (203 Czech Republic), Petr BENEŠ (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic).
• Edition: Genes Immun, United Kingdom, Nature Publishing Group, 2002, 1466-4879.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.060
• RIV identification code: RIV/00216224:14110/02:00005507
• Organization unit: Faculty of Medicine
• UT WoS: 000177380000007
• Keywords in English: gene; polymorphism; PAI-1; periodontitis
• Tags: gene, PAI-1, periodontitis, polymorphism

Abstract

Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.

Links

• MSM 141100002, plan (intention): Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases