2002
The effect of sigma ligand haloperidol in guinea pig atrial preparation
NOVÁKOVÁ, MarieZákladní údaje
Originální název
The effect of sigma ligand haloperidol in guinea pig atrial preparation
Autoři
NOVÁKOVÁ, Marie (203 Česká republika, garant)
Vydání
Piešťany, Slovak Republic. 78. Physiological Days. s. 56-56, 2002
Nakladatel
ÚMFG SAV, Bratislava.
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
30105 Physiology
Stát vydavatele
Slovensko
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14330/02:00005517
Organizační jednotka
Fakulta informatiky
Klíčová slova anglicky
sigma receptor; haloperidol; modulation of contractility
Změněno: 31. 5. 2003 08:22, RNDr. JUDr. Vladimír Šmíd, CSc.
Anotace
V originále
Sigma receptors ligands play a role in modulation of contractility in rat myocardium. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. Marked positive inotropic effect previously described in rat cardiomyocytes (increase in the twitch amplitude ranging from 50 to 90 %, with maximal effect in the 5th minute of perfusion) was observed. The mechanical restitution pattern is not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration.
Návaznosti
| GA102/01/1494, projekt VaV |
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| GA305/98/P206, projekt VaV |
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