Association of three polymorphisms in the gene coding for
endothelin-1 (ET-1) with the essential hypertension, overweight
and smoking.

J 2002

Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.

VAŠKŮ, Anna, Svatava TSCHÖPLOVÁ, Jan MUŽÍK, Miroslav SOUČEK, Jiří VÁCHA et. al.

Základní údaje

Originální název

Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.

Autoři

VAŠKŮ, Anna (203 Česká republika, garant), Svatava TSCHÖPLOVÁ (203 Česká republika), Jan MUŽÍK (203 Česká republika), Miroslav SOUČEK (203 Česká republika) a Jiří VÁCHA (203 Česká republika)

Vydání

Experimental and Clinical Cardiology, Kanada, xxxx, 2002

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/02:00005720

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

endothelin-1; gene polymorphism; essential hypertension; BMI; smoking

Štítky

bmi, Endothelin-1, essential hypertension, Gene polymorphism, Smoking

Změněno: 9. 3. 2004 11:45, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

The aim of the study is to evaluate association of three endothelin-1 (ET-1) gene polymorphisms with the essential hypertension as well as with two risk cardiovascular factors- BMI and smoking. Three gene polymorphisms and the genotype and/or allelic distributions were compared between normotensive healthy volunteers and patients with essential hypertension. Genetic association of the three genotypes with BMI and smoking status was calculated. CA/CT dinucleotide repeat polymorphism, the G (8002) A polymorphism and 3A/-4A polymorphism (-138 insertion/ deletion) in the gene coding for endothelin-1 (ET-1, 6p21.3) in 398 subjects, 192 normotensives (healthy volunteers) and 206 patients with essential hypertension. The normotension was verified by 24-h ambulatory blood pressure monitoring (ABPM, SpaceLab 90 207). Significant inner associations were observed among all three polymophisms, which suggests possible complex interaction inside the gene. The only significant difference in single gene case-control study we proved in the lengths of allelic variants of CA/CT dinucletide repeat polymorphism. In hypertensives, the alleles of G (8002) A and -3A/-4A ET-1 polymorphisms were found to be significantly associated (G with -3A and A with -4A). None of the ET-1 gene polymorphism was associated with BMI. A highly significant increase of -3A allele of -3A/-4A ET-1 polymorphism was proved in hypertensive men who were smokers 1 (persons which are and/or have been smoking at least 7 cigarettes a week for at least one year anytime in their life) compared to never-smoking hypertensive men (OR 1.54, 95% CI 1.03-2.32, P=0.009. Smoking seems to be an independent risk cardiovascular factor genetically codetermined by the endothelin-1 gene variant.

Návaznosti

GA306/96/0099, projekt VaV

Název: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Grantová agentura ČR, Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Anna, Svatava TSCHÖPLOVÁ, Jan MUŽÍK, Miroslav SOUČEK a Jiří VÁCHA. Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. Experimental and Clinical Cardiology. Kanada: xxxx, 2002, roč. 7/2003, č. 4, s. 201-204.

@article{403503,
   author = {Vašků, Anna and Tschöplová, Svatava and Mužík, Jan and Souček, Miroslav and Vácha, Jiří},
   article_location = {Kanada},
   article_number = {4},
   keywords = {endothelin-1; gene polymorphism; essential hypertension; BMI; smoking},
   language = {eng},
   journal = {Experimental and Clinical Cardiology},
   title = {Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.},
   volume = {7/2003},
   year = {2002}
}

TY  - JOUR
ID  - 403503
AU  - Vašků, Anna - Tschöplová, Svatava - Mužík, Jan - Souček, Miroslav - Vácha, Jiří
PY  - 2002
TI  - Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.
JF  - Experimental and Clinical Cardiology
VL  - 7/2003
IS  - 4
SP  - 201-204
EP  - 201-204
PB  - xxxx
KW  - endothelin-1
KW  - gene polymorphism
KW  - essential hypertension
KW  - BMI
KW  - smoking
N2  - The aim of the study is to evaluate association of three endothelin-1 (ET-1) gene polymorphisms with the essential hypertension as well as with two risk cardiovascular factors- BMI and smoking. Three gene polymorphisms and the genotype and/or allelic distributions were compared between normotensive healthy volunteers and patients with essential hypertension. Genetic association of the three genotypes with BMI and smoking status was calculated. CA/CT dinucleotide repeat polymorphism, the G (8002) A polymorphism and 3A/-4A polymorphism (-138 insertion/ deletion) in the gene coding for endothelin-1 (ET-1, 6p21.3) in 398 subjects, 192 normotensives (healthy volunteers) and 206 patients with essential hypertension. The normotension was verified by 24-h ambulatory blood pressure monitoring (ABPM, SpaceLab 90 207). Significant inner associations were observed among all three polymophisms, which suggests possible complex interaction inside the gene. The only significant difference in single gene case-control study we proved in the lengths of allelic variants of CA/CT dinucletide repeat polymorphism. In hypertensives, the alleles of G (8002) A and -3A/-4A ET-1 polymorphisms were found to be significantly associated (G with -3A and A with -4A). None of the ET-1 gene polymorphism was associated with BMI. A highly significant increase of -3A allele of -3A/-4A ET-1 polymorphism was proved in hypertensive men who were smokers 1 (persons which are and/or have been smoking at least 7 cigarettes a week for at least one year anytime in their life) compared to never-smoking hypertensive men (OR 1.54, 95% CI 1.03-2.32, P=0.009. Smoking seems to be an independent risk cardiovascular factor genetically codetermined by the endothelin-1 gene variant.
ER  -

VAŠKŮ, Anna, Svatava TSCHÖPLOVÁ, Jan MUŽÍK, Miroslav SOUČEK a Jiří VÁCHA. Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. \textit{Experimental and Clinical Cardiology}. Kanada: xxxx, 2002, roč.~7/2003, č.~4, s.~201-204.

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