An association of BMI with and A(-6)G, M235T and T174M
polymorphisms in angiotensinogen gene in essential hypertension

J 2002

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ a Andrea STEJSKALOVÁ

Základní údaje

Originální název

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Autoři

VAŠKŮ, Anna (203 Česká republika, garant), Miroslav SOUČEK (203 Česká republika), Svatava TSCHÖPLOVÁ (203 Česká republika) a Andrea STEJSKALOVÁ (203 Česká republika)

Vydání

Journal of Human Hypertension, Velká Británie, Nature Publishing Group, 2002, 0950-9240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.366

Kód RIV

RIV/00216224:14110/02:00005721

Organizační jednotka

Lékařská fakulta

UT WoS

000176625500010

Klíčová slova anglicky

BMI; obesity; essential hypertension; angiotensinogen; gene polymorphism; and smoking; risk factor

Štítky

and smoking, angiotensinogen, bmi, essential hypertension, Gene polymorphism, obesity, risk factor

Změněno: 18. 6. 2009 09:56, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control group vs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr=0.0002 for AA+AG of A(-6)G ATG, Pcorr= 0.01 for CC+CT of T(174)M ATG and Pcorr=0.01 for MT+TT of M235T ATG). No functional relations among obesity and the examined polymorphisms in vivo are known. We conclude that different distribution of BMI could influence results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.

Návaznosti

GA306/93/2192, projekt VaV

Název: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Grantová agentura ČR, Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense

GA306/96/0099, projekt VaV

Název: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Grantová agentura ČR, Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ a Andrea STEJSKALOVÁ. An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. Journal of Human Hypertension. Velká Británie: Nature Publishing Group, 2002, roč. 2002, č. 16, s. 427-430. ISSN 0950-9240.

@article{403504,
   author = {Vašků, Anna and Souček, Miroslav and Tschöplová, Svatava and Stejskalová, Andrea},
   article_location = {Velká Británie},
   article_number = {16},
   keywords = {BMI; obesity; essential hypertension; angiotensinogen; gene polymorphism; and smoking; risk factor},
   language = {eng},
   issn = {0950-9240},
   journal = {Journal of Human Hypertension},
   title = {An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension},
   volume = {2002},
   year = {2002}
}

TY  - JOUR
ID  - 403504
AU  - Vašků, Anna - Souček, Miroslav - Tschöplová, Svatava - Stejskalová, Andrea
PY  - 2002
TI  - An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension
JF  - Journal of Human Hypertension
VL  - 2002
IS  - 16
SP  - 427-430
EP  - 427-430
PB  - Nature Publishing Group
SN  - 09509240
KW  - BMI
KW  - obesity
KW  - essential hypertension
KW  - angiotensinogen
KW  - gene polymorphism
KW  - and smoking
KW  - risk factor
N2  - The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control group vs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr=0.0002 for AA+AG of A(-6)G ATG, Pcorr= 0.01 for CC+CT of T(174)M ATG and Pcorr=0.01 for MT+TT of M235T ATG). No functional relations among obesity and the examined polymorphisms in vivo are known. We conclude that different distribution of BMI could influence results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.
ER  -

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ a Andrea STEJSKALOVÁ. An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. \textit{Journal of Human Hypertension}. Velká Británie: Nature Publishing Group, 2002, roč.~2002, č.~16, s.~427-430. ISSN~0950-9240.

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