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@article{403594,
author = {Vašků, Vladimír and Kaňková, Kateřina and Vašků, Anna and Mužík, Jan and Izakovičová Hollá, Lydie and Semrádová, Věra and Vácha, Jiří},
article_location = {Německo},
article_number = {2},
keywords = {RAGE-gene polymorphism-psoriasis-antioxidant status},
language = {eng},
issn = {0340-3696},
journal = {Archives of Dermatological Research},
title = {Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis},
volume = {294},
year = {2002}
}
TY - JOUR
ID - 403594
AU - Vašků, Vladimír - Kaňková, Kateřina - Vašků, Anna - Mužík, Jan - Izakovičová Hollá, Lydie - Semrádová, Věra - Vácha, Jiří
PY - 2002
TI - Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis
JF - Archives of Dermatological Research
VL - 294
IS - 2
SP - 127
EP - 127
PB - Springer Verlag
SN - 03403696
KW - RAGE-gene polymorphism-psoriasis-antioxidant status
N2 - Having in mind relations between oxidative stress, psoriasis and common disorders, associations of polymorphisms in gene coding for RAGE with plaque psoriasis considering personal history of diabetes mellitus, cardiovascular disorders, cancer and allergy were investigated.Allele frequencies and genotype combinations of the four polymorphisms in RAGE gene (6p 21.3, G82S, 1704G/T, 2184A/G and 2245A/G) were compared in a case-control study comprising 272 subjects (130 patients with plaque psoriasis and 142 healthy control subjects of comparable age and sex distribution). Polymerase chain reaction with subsequent restriction analysis were used for detection of allele variants. No correlations of alleles and/or genotypes of all examined RAGE polymorphism with positive familiar history of psoriasis and/or early onset of psoriasis manifestation (less than 40 years) were found. The G82S, 1704G/T and 2245A/G RAGE polymorphisms were associated neither with plaque psoriasis nor with personal history of common diseases (diabetes mellitus, cardiovascular disorders, cancer, allergy). Statistically significant rise in the 2184G allele frequency of 2184A/G RAGE polymorphism was observed in psoriatics compared to control group (odds ratio 1.40, 95% CI 0.88-2.21, P=0.005, after correction for the number of comparisons Pcorr=0.02). The 2184G allele occurred more often in psoriatic patients with negative personal history of diabetes mellitus (odds ratio 1.07, 95% CI 0.69-1.64, P=0.007) and with negative personal history of cardiovascular diseases (odds ratio 1.7, 95% CI 1.08-2.07, P=0.001). The distribution of common genotypes of the four polymorphisms (81 variants) did not differ signficantly between psoriatic and control group. The identification of novel susceptibility gene RAGE - provides some insight into the precise biochemical pathway that control plaque psoriasis manifestation. Because genetic background of psoriasis is supposed to be multigenic, interaction with other several genes with higher common relative genetic risk for psoriasis manifestation could be expected. Complicated linkage disequilibria within HLA system genes in 6p21.3 region cannot be excluded.
ER -
VAŠKŮ, Vladimír, Kateřina KAŇKOVÁ, Anna VAŠKŮ, Jan MUŽÍK, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ a Jiří VÁCHA. Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis. \textit{Archives of Dermatological Research}. Německo: Springer Verlag, 2002, roč.~294, č.~2, s.~127-130. ISSN~0340-3696.
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