Genotype association of C(-735)T polymorphism in matrix
metalloproteinase 2 gene with G(8002)A endothelin 1 gene with
plaque psoriasis

J 2002

Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis

VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ et. al.

Základní údaje

Originální název

Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis

Autoři

VAŠKŮ, Vladimír (203 Česká republika, garant), Anna VAŠKŮ (203 Česká republika), Svatava TSCHÖPLOVÁ (203 Česká republika), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika), Věra SEMRÁDOVÁ (203 Česká republika) a Jiří VÁCHA (203 Česká republika)

Vydání

Dermatology, Basel, Karger, 2002, 1018-8665

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.973

Kód RIV

RIV/00216224:14110/02:00006175

Organizační jednotka

Lékařská fakulta

UT WoS

000176566500002

Klíčová slova anglicky

MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis

Štítky

Endothelin-1, Gene polymorphism, MMP-2, Plaque psoriasis

Změněno: 18. 6. 2009 09:58, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. Dermatology. Basel: Karger, 2002, roč. 204, č. 4, s. 262-265. ISSN 1018-8665.

@article{404296,
   author = {Vašků, Vladimír and Vašků, Anna and Tschöplová, Svatava and Izakovičová Hollá, Lydie and Semrádová, Věra and Vácha, Jiří},
   article_location = {Basel},
   article_number = {4},
   keywords = {MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis},
   language = {eng},
   issn = {1018-8665},
   journal = {Dermatology},
   title = {Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis},
   volume = {204},
   year = {2002}
}

TY  - JOUR
ID  - 404296
AU  - Vašků, Vladimír - Vašků, Anna - Tschöplová, Svatava - Izakovičová Hollá, Lydie - Semrádová, Věra - Vácha, Jiří
PY  - 2002
TI  - Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis
JF  - Dermatology
VL  - 204
IS  - 4
SP  - 262
EP  - 262
PB  - Karger
SN  - 10188665
KW  - MMP-2
KW  - Endothelin-1
KW  - Gene polymorphism
KW  - Plaque psoriasis
N2  - Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.
ER  -

VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. \textit{Dermatology}. Basel: Karger, 2002, roč.~204, č.~4, s.~262-265. ISSN~1018-8665.

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