2002
Effect of sigma ligand haloperidol in guinea pig heart preparations
NOVÁKOVÁ, MarieZákladní údaje
Originální název
Effect of sigma ligand haloperidol in guinea pig heart preparations
Autoři
NOVÁKOVÁ, Marie (203 Česká republika, garant)
Vydání
Journal of Molecular and Cellular Cardiology, London, Academic Press, 2002, 0022-2828
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30105 Physiology
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 4.091
Kód RIV
RIV/00216224:14110/02:00006189
Organizační jednotka
Lékařská fakulta
UT WoS
000176496800316
Klíčová slova anglicky
cardiac sigma receptor; haloperidol; contractility; mechanical restitution
Změněno: 3. 7. 2002 12:12, prof. MUDr. Marie Nováková, Ph.D.
Anotace
V originále
The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentration.
Návaznosti
| GA102/01/1494, projekt VaV |
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| GA305/98/P206, projekt VaV |
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