Synthesis of New 4-(4-(4-Methoxyphenyl)-5-(2-phenylquinazolin-4-yl)-1,3-Thiazol-2-yl)morpholine and N4-(5-(4-Methoxyphenyl)-1,3-oxathiol-2-yliden)-(2-phenylquinazolin-4-yl)-amine

MOHAMED, Walid Fathalla, Jaromír MAREK and Pavel PAZDERA. Synthesis of New 4-(4-(4-Methoxyphenyl)-5-(2-phenylquinazolin-4-yl)-1,3-Thiazol-2-yl)morpholine and N4-(5-(4-Methoxyphenyl)-1,3-oxathiol-2-yliden)-(2-phenylquinazolin-4-yl)-amine. Heterocyclic Communications. London: Freund Publishing House, 2002, vol. 2002, No 1, p. 157-160. ISSN 0793-0283.

Basic information

• Original name: Synthesis of New 4-(4-(4-Methoxyphenyl)-5-(2-phenylquinazolin-4-yl)-1,3-Thiazol-2-yl)morpholine and N4-(5-(4-Methoxyphenyl)-1,3-oxathiol-2-yliden)-(2-phenylquinazolin-4-yl)-amine
• Authors: MOHAMED, Walid Fathalla (818 Egypt), Jaromír MAREK (203 Czech Republic) and Pavel PAZDERA (203 Czech Republic, guarantor).
• Edition: Heterocyclic Communications, London, Freund Publishing House, 2002, 0793-0283.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10401 Organic chemistry
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.326
• RIV identification code: RIV/00216224:14310/02:00006268
• Organization unit: Faculty of Science
• Keywords in English: quinazolines; 1;3-oxathioles; 1;3-thiazoles; domino-reaction; cyclization; retro-cyclization
• Tags: 1, 3-oxathioles, 3-thiazoles, cyclization, DOMINO-REACTION, quinazolines, retro-cyclization

Abstract

The reaction of N3,N3-(3-oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-yliden)thiourea with 4-methoxyphenacyl bromide afforded either the kinetically controlled reversible reaction product N4-[5-(4-methoxyphenyl)-1,3-oxathiol-2-yliden]-(2-phenylquinazolin-4-yl)-amine or the thermo-dynamically controlled reaction product 4-[4-(4-methoxyphenyl)-5-(2-phenylquinazolin-4-yl) -4,5-dihydro-1,3-thiazol-2-yl]morpholine via domino-reaction by two different reaction pathways.

Links

• GA203/01/1333, research and development project: Name: Chalkogenorganické sloučeniny - příprava, transformace a strukturní studie

Investor: Czech Science Foundation, Chalcogen organic compounds - synthesis, transformation and structure elucidation

• MSM 143100011, plan (intention): Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles