NOVÁKOVÁ, Marie, Zuzana NOVÁKOVÁ and Jiří MOUDR. Mechanical Restitution in Left and Right Guinea Pig Ventricular Preparations. Scripta medica. Brno: Lékařská fakulta Brno, 2002, vol. 75, No 4, p. 187-194. ISSN 1211-3395.
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Basic information
Original name Mechanical Restitution in Left and Right Guinea Pig Ventricular Preparations
Name in Czech Mechanická restituce u srdečních preparátů morčete z pravé a levé komory
Authors NOVÁKOVÁ, Marie (203 Czech Republic, guarantor), Zuzana NOVÁKOVÁ (203 Czech Republic) and Jiří MOUDR (203 Czech Republic).
Edition Scripta medica, Brno, Lékařská fakulta Brno, 2002, 1211-3395.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/02:00006315
Organization unit Faculty of Medicine
Keywords in English Mechanical restitution; papillary muscle; heart; left and right ventricles; guinea pig
Tags guinea pig, heart, left and right ventricles, Mechanical restitution, papillary muscle
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Marie Nováková, Ph.D., učo 1188. Changed: 23/6/2009 18:08.
Abstract
The study was focused on identification of possible differences in the onset and time course of mechanical restitution in guinea pig multicellular heart preparations, i.e., papillary muscles from the right and left ventricles. Stimulated twitches of both preparations mounted in a horizontal perfusion bath were recorded simultaneously. Mechanical restitution curves were constructed at 25C and 35C and at stimulation rates of 0.5 Hz, 1 Hz and 2 Hz. No statistically significant differences in restitution curves of both preparations were found. It can be concluded that, in the assessment of mechanical behaviour of the heart, the guinea pig left ventricular papillary muscle appears to be a suitable substitute for the conventionally employed right ventricular papillary muscles.
Abstract (in Czech)
Tato studie srovnává mechanickou restituci (začátek a časový průběh) u papilárních svalů z pravé a levé komory srdce morčete. Jedná se o velmi cenný model, hlavně pro farmakologické studie. Bylo prokázáno, že papilární sval z levé komory, je-li dostatečně tenký a netrpí tedy ischemií, může nahradit běžně používaný sval z komory pravé.
Links
GA102/01/1494, research and development projectName: Optické snímání akčních potenciálů a jeho využití v kardiologii
Investor: Czech Science Foundation, Optical recording of action potentials and its application in cardiology
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