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@article{405100,
author = {Maloň, M. and Trávníček, Z. and Maryško, M. and Marek, Jaromír and Doležal, K. and Rolčík, J. and Strnad, M.},
article_location = {Dordrecht},
article_number = {6},
keywords = {BIOLOGICAL ACTIVITY; 6-(2-CHLOROBENZYLAMINO)PURINE},
language = {eng},
issn = {0340-4285},
journal = {Transition Metal Chemistry},
title = {Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.},
volume = {27},
year = {2002}
}
TY - JOUR
ID - 405100
AU - Maloň, M. - Trávníček, Z. - Maryško, M. - Marek, Jaromír - Doležal, K. - Rolčík, J. - Strnad, M.
PY - 2002
TI - Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.
JF - Transition Metal Chemistry
VL - 27
IS - 6
SP - 580
EP - 580
PB - Kluwer Academic Publishers
SN - 03404285
KW - BIOLOGICAL ACTIVITY
KW - 6-(2-CHLOROBENZYLAMINO)PURINE
N2 - Copper(II) complexes with 6-(4-chlorobenzylamino)purine (HL) have been prepared and characterized by elemental analysis, electronic, i.r., ES + mass and C-13-n.m.r. spectra, and by magnetic and conductivity data. Based on these physical methods, mainly the temperature dependence of magnetic susceptibility data, we conclude that the complexes are: [Cu-2(mu-Cl)(2)(mu-HL)(2)Cl-2] (1) and [CuCl3(H+L)(2)]Cl (2). They have been studied for their possible antitumour activity against human malignant melanoma G-361, human osteogenic sarcoma HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma MCF7 cells in vitro. The IC50 values were determined by calcein AM assay. The molecular structure of 6-(4-chlorobenzylamino)purinium perchlorate, i.e. a protonated form of the free HL ligand, has been determined by a single crystal X-ray analysis.
ER -
MALOŇ, M., Z. TRÁVNÍČEK, M. MARYŠKO, Jaromír MAREK, K. DOLEŽAL, J. ROLČÍK and M. STRNAD. Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate. \textit{Transition Metal Chemistry}. Dordrecht: Kluwer Academic Publishers, 2002, vol.~27, No~6, p.~580-586. ISSN~0340-4285.
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