MALOŇ, M., Z. TRÁVNÍČEK, M. MARYŠKO, Jaromír MAREK, K. DOLEŽAL, J. ROLČÍK and M. STRNAD. Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate. Transition Metal Chemistry. Dordrecht: Kluwer Academic Publishers, 2002, vol. 27, No 6, p. 580-586. ISSN 0340-4285.
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Basic information
Original name Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.
Authors MALOŇ, M. (203 Czech Republic), Z. TRÁVNÍČEK (203 Czech Republic), M. MARYŠKO (203 Czech Republic), Jaromír MAREK (203 Czech Republic, guarantor), K. DOLEŽAL (203 Czech Republic), J. ROLČÍK (203 Czech Republic) and M. STRNAD (203 Czech Republic).
Edition Transition Metal Chemistry, Dordrecht, Kluwer Academic Publishers, 2002, 0340-4285.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.949
RIV identification code RIV/00216224:14310/02:00006358
Organization unit Faculty of Science
Keywords in English BIOLOGICAL ACTIVITY; 6-(2-CHLOROBENZYLAMINO)PURINE
Tags 6-(2-CHLOROBENZYLAMINO)PURINE, BIOLOGICAL ACTIVITY
Changed by Changed by: doc. RNDr. Jaromír Marek, Ph.D., učo 1989. Changed: 21/5/2003 10:36.
Abstract
Copper(II) complexes with 6-(4-chlorobenzylamino)purine (HL) have been prepared and characterized by elemental analysis, electronic, i.r., ES + mass and C-13-n.m.r. spectra, and by magnetic and conductivity data. Based on these physical methods, mainly the temperature dependence of magnetic susceptibility data, we conclude that the complexes are: [Cu-2(mu-Cl)(2)(mu-HL)(2)Cl-2] (1) and [CuCl3(H+L)(2)]Cl (2). They have been studied for their possible antitumour activity against human malignant melanoma G-361, human osteogenic sarcoma HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma MCF7 cells in vitro. The IC50 values were determined by calcein AM assay. The molecular structure of 6-(4-chlorobenzylamino)purinium perchlorate, i.e. a protonated form of the free HL ligand, has been determined by a single crystal X-ray analysis.
Links
GA203/00/0152, research and development projectName: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty
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