| NOVÁKOVÁ, Marie. The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation. Physiological Research. Praha: Inst of Physiology, Academy of Sciences, 2002, roč. 51, č. 4, s. 29P, 1 s. ISSN 0862-8408. |
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@article{407493,
author = {Nováková, Marie},
article_location = {Praha},
article_number = {4},
keywords = {guinea pig; atrium; sigma receptor; haloperidol; mechanical restitution},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation},
volume = {51},
year = {2002}
}
TY - JOUR
ID - 407493
AU - Nováková, Marie
PY - 2002
TI - The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation
JF - Physiological Research
VL - 51
IS - 4
SP - 29P
EP - 29P
PB - Inst of Physiology, Academy of Sciences
SN - 08628408
KW - guinea pig
KW - atrium
KW - sigma receptor
KW - haloperidol
KW - mechanical restitution
N2 - Our previous experiments with sigma receptor ligands in rat myocytes and rat isolated hearts suggested that these receptors may play a role in modulation of contractility. The aim of the present study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. The effects of haloperidol on the amplitude of contraction and on the restitution of contractility were investigated. The positive inotropic effect of haloperidol was confirmed also in guinea pig atrial preparations. According to its effect on the mechanical restitution we can assume that it is mediated via increased cytoplasmatic Ca2+concentration.
ER -
NOVÁKOVÁ, Marie. The Effect of Sigma Ligand Haloperidol in Guinea Pig Atrial Preparation. \textit{Physiological Research}. Praha: Inst of Physiology, Academy of Sciences, 2002, roč.~51, č.~4, s.~29P, 1 s. ISSN~0862-8408.
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