Arrhythmogenic effect of extracellular K-depletion is prevented
by the transverse-axial tubular system in a ventricular cardiac
cell model

J 2002

Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA

Základní údaje

Originální název

Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model

Autoři

PÁSEK, Michal (203 Česká republika, garant), Georges CHRISTÉ (250 Francie) a Jiří ŠIMURDA (203 Česká republika)

Vydání

Scripta Medica Fac.Med.Univ.Masaryk.Brun. Brno, Faculty of Medicine, Masaryk University, 2002, 1211-3395

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/02:00007136

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

ventricular cell; low external [K]; tubular system; quantitative modelling

Štítky

low external [K], Quantitative modelling, tubular system, ventricular cell

Změněno: 6. 11. 2003 16:46, doc. Ing. Michal Pásek, Ph.D.

Anotace

V originále

In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage.

Návaznosti

GP204/02/D129, projekt VaV

Název: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Investor: Grantová agentura ČR, Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Citovat

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA. Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model. Scripta Medica Fac.Med.Univ.Masaryk.Brun. Brno: Faculty of Medicine, Masaryk University, 2002, roč. 75, č. 4, s. 179-186. ISSN 1211-3395.

@article{483035,
   author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
   article_location = {Brno},
   article_number = {4},
   keywords = {ventricular cell; low external [K]; tubular system; quantitative modelling},
   language = {eng},
   issn = {1211-3395},
   journal = {Scripta Medica Fac.Med.Univ.Masaryk.Brun.},
   title = {Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model},
   volume = {75},
   year = {2002}
}

TY  - JOUR
ID  - 483035
AU  - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY  - 2002
TI  - Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model
JF  - Scripta Medica Fac.Med.Univ.Masaryk.Brun.
VL  - 75
IS  - 4
SP  - 179
EP  - 179
PB  - Faculty of Medicine, Masaryk University
SN  - 12113395
KW  - ventricular cell
KW  - low external [K]
KW  - tubular system
KW  - quantitative modelling
N2  - In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage.
ER  -

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA. Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model. \textit{Scripta Medica Fac.Med.Univ.Masaryk.Brun.}. Brno: Faculty of Medicine, Masaryk University, 2002, roč.~75, č.~4, s.~179-186. ISSN~1211-3395.

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