| KOZÁK, Milan, Lydie IZAKOVIČOVÁ HOLLÁ, Lubomír KŘIVAN, Anna VAŠKŮ, Milan SEPŠI, Bořivoj SEMRÁD and Jiří VÁCHA. Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia. Medical Science Monitor (International Medical Journal of Experimental and Clinical Research). USA: International Scientific Literature, Inc, 2002, vol. 8, No 5, p. 164-167. ISSN 1234-1010. |
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@article{483327,
author = {Kozák, Milan and Izakovičová Hollá, Lydie and Křivan, Lubomír and Vašků, Anna and Sepši, Milan and Semrád, Bořivoj and Vácha, Jiří},
article_location = {USA},
article_number = {5},
keywords = {gene; endothelin; polymorphism; ET-1; arrhythmia; defibrillator},
language = {eng},
issn = {1234-1010},
journal = {Medical Science Monitor (International Medical Journal of Experimental and Clinical Research)},
title = {Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia},
volume = {8},
year = {2002}
}
TY - JOUR
ID - 483327
AU - Kozák, Milan - Izakovičová Hollá, Lydie - Křivan, Lubomír - Vašků, Anna - Sepši, Milan - Semrád, Bořivoj - Vácha, Jiří
PY - 2002
TI - Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia
JF - Medical Science Monitor (International Medical Journal of Experimental and Clinical Research)
VL - 8
IS - 5
SP - 164
EP - 164
PB - International Scientific Literature, Inc
SN - 12341010
KW - gene
KW - endothelin
KW - polymorphism
KW - ET-1
KW - arrhythmia
KW - defibrillator
N2 - The endothelins are peptides with vasoconstriction and growth-promoting properties. Endothelin-1 (ET-1) is known for its direct positive inotropic and chronotropic effects on isolated heart, and for growth effects. The aim of this pilot study was to investigate the frequency distribution of a common polymorphism of the endothelin gene and its possible relation to the hemodynamic consequences of malignant ventricular arrhythmia in patients with structural heart disease. We studied 26 consecutive patients with malignant ventricular arrhythmia and implantable cardioverter defibrillators (ICD), mean age 62.7 years, mean LVEF 0.37. The Taq polymorphism of ET-1 was detected using our original PCR method. Out of the 26 patients, 9 (34%) had reccurent palpitations and 8 (30.8%) had syncopes during their malignant arrhythmic episodes. 19 of the patients were receiving amiodarone after ICD implantation, 7 were not. 15 patients had the (++) and 11 had (+-) ET-1 genotype, none had the (--) genotype. The risk of syncopes was associated with the (++) genotype (p=0.01). Patients with amiodarone had a significantly higher frequency of the (++) genotype (p=0.011). All our results suggested that the presence of the (++) ET-1 genotype in patients with structural heart disease, severe left ventricular dysfunction, and malignant ventricular arrhythmia put these patients at a higher risk of hemodynamic collapse during arrhythmic episodes.
ER -
KOZÁK, Milan, Lydie IZAKOVIČOVÁ HOLLÁ, Lubomír KŘIVAN, Anna VAŠKŮ, Milan SEPŠI, Bořivoj SEMRÁD and Jiří VÁCHA. Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia. \textit{Medical Science Monitor (International Medical Journal of Experimental and Clinical Research)}. USA: International Scientific Literature, Inc, 2002, vol.~8, No~5, p.~164-167. ISSN~1234-1010.
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