HORKÝ, Marcel, Vladimír KOTALA, Milan ANTON a Jozefa WESIERSKA-GADEK. Nucleolus and Apoptosis. Annals of the New York Academy of Sciences. USA: New York Academy of Sciences, 2002, x, č. 973, s. 258-263. ISSN 0077-8923. |
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@article{483356, author = {Horký, Marcel and Kotala, Vladimír and Anton, Milan and WesierskaandGadek, Jozefa}, article_location = {USA}, article_number = {973}, keywords = {nucleolus; proliferation; apoptosis}, language = {eng}, issn = {0077-8923}, journal = {Annals of the New York Academy of Sciences}, title = {Nucleolus and Apoptosis}, volume = {x}, year = {2002} }
TY - JOUR ID - 483356 AU - Horký, Marcel - Kotala, Vladimír - Anton, Milan - Wesierska-Gadek, Jozefa PY - 2002 TI - Nucleolus and Apoptosis JF - Annals of the New York Academy of Sciences VL - x IS - 973 SP - 258 EP - 258 PB - New York Academy of Sciences SN - 00778923 KW - nucleolus KW - proliferation KW - apoptosis N2 - The nucleolus represents a highly dynamic nuclear compartment of the interphase nucleus. It plays a key role in ribosome biogenesis. The number of nucleoli, their size, and their activity increase in exponentially growing cells; therefore these parameters reflect the proliferating activity of the cells. Nucleolar changes and pleomorphism associated with overt proliferation of tumor cells have also been documented by immunohistochemical and ultrastructural studies. Contrary to cell proliferation, cytostatics-induced changes of nucleolar phenotype in malignant cells point to a potential role of nucleolar components in the execution of active cell death. It can be concluded that the plurifunctionality of nucleoli regarding cell proliferation and apoptosis could open new vistas toward understanding dysregulation in malignant cells. ER -
HORKÝ, Marcel, Vladimír KOTALA, Milan ANTON a Jozefa WESIERSKA-GADEK. Nucleolus and Apoptosis. \textit{Annals of the New York Academy of Sciences}. USA: New York Academy of Sciences, 2002, x, č.~973, s.~258-263. ISSN~0077-8923.
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