Antidepressant-like effects of amisulpride in bubectomized male
rats

D 2002

Antidepressant-like effects of amisulpride in bubectomized male rats

PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Antidepressant-like effects of amisulpride in bubectomized male rats

Autoři

PISTOVČÁKOVÁ, Jana (703 Slovensko) a Alexandra ŠULCOVÁ (203 Česká republika, garant)

Vydání

Častá, Slovakia, Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society, s. 66-66, 2002

Nakladatel

Czech and Slovak Neurochemical Society

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/02:00007505

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

antidepressant; olfactory bulbectomy; amisulpride; rat

Štítky

amisulpride, antidepressant, olfactory bulbectomy, rat

Změněno: 19. 5. 2003 14:26, MUDr. Jana Pistovčáková, Ph.D.

Anotace

V originále

Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Rats with bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambulation) in sham-operated and bulbectomized rats were studied in an open field arena of the infrared beam-based system (Acti-track, Panlab, Spain). There was no effect on locomotion after a single dose nor after 7 day amisulpride medication (3.5 mg/kg/d i.p.) in both sham-operated and OB rats. However, on the contrary to sham-operated animals (no changes in locomotion) the hyperactive OB rats responded to the prolonged (another 7 days) amisulpride medication (with higher dose of 7.0 mg/kg/day i.p.) with a significant decrease of their hyperactive ambulation. These results provide further support for announced preclinical and clinical suggestions that amisulpride at least at some doses possesses potent antidepressant activity.

Citovat

PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Antidepressant-like effects of amisulpride in bubectomized male rats. In Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society. Častá, Slovakia: Czech and Slovak Neurochemical Society, 2002, s. 66.

@inproceedings{484269,
   author = {Pistovčáková, Jana and Šulcová, Alexandra},
   address = {Častá, Slovakia},
   booktitle = {Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society},
   keywords = {antidepressant; olfactory bulbectomy; amisulpride; rat},
   language = {eng},
   location = {Častá, Slovakia},
   note = {Programme and Abstracts},
   pages = {66-66},
   publisher = {Czech and Slovak Neurochemical Society},
   title = {Antidepressant-like effects of amisulpride in bubectomized male rats},
   year = {2002}
}

TY  - JOUR
ID  - 484269
AU  - Pistovčáková, Jana - Šulcová, Alexandra
PY  - 2002
TI  - Antidepressant-like effects of amisulpride in bubectomized male rats
PB  - Czech and Slovak Neurochemical Society
CY  - Častá, Slovakia
N1  - Programme and Abstracts
KW  - antidepressant
KW  - olfactory bulbectomy
KW  - amisulpride
KW  - rat
N2  - Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Rats with bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambulation) in sham-operated and bulbectomized rats were studied in an open field arena of the infrared beam-based system (Acti-track, Panlab, Spain). There was no effect on locomotion after a single dose nor after 7 day amisulpride medication (3.5 mg/kg/d i.p.) in both sham-operated and OB rats. However, on the contrary to sham-operated animals (no changes in locomotion) the hyperactive OB rats responded to the prolonged (another 7 days) amisulpride medication (with higher dose of 7.0 mg/kg/day i.p.) with a significant decrease of their hyperactive ambulation. These results provide further support for announced preclinical and clinical suggestions that amisulpride at least at some doses possesses potent antidepressant activity.
ER  -

PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Antidepressant-like effects of amisulpride in bubectomized male rats. In \textit{Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society}. Častá, Slovakia: Czech and Slovak Neurochemical Society, 2002, s.~66.

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