KAŠPAROVSKÁ, Jitka, Hana HŘÍBKOVÁ, Renáta HLOUŠKOVÁ, Miroslav NOVOTNÝ, Kateřina GLÁSLOVÁ, Vladimír ŠIMEK, Vladimír MIKEŠ, Petr ZVOLSKÝ and Omar ŠERÝ. TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice (TaqI A polymorphism of the DRD2 gene and alcoholism in the Czech Republic). Česká a slovenská psychiatrie. Praha: ČLS J.E. Purkyně, 2003, vol. 99, No 1, p. 5-9. ISSN 1212-0383.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice
Name (in English) TaqI A polymorphism of the DRD2 gene and alcoholism in the Czech Republic
Authors KAŠPAROVSKÁ, Jitka (203 Czech Republic), Hana HŘÍBKOVÁ (203 Czech Republic), Renáta HLOUŠKOVÁ (203 Czech Republic), Miroslav NOVOTNÝ (203 Czech Republic), Kateřina GLÁSLOVÁ (203 Czech Republic), Vladimír ŠIMEK (203 Czech Republic), Vladimír MIKEŠ (203 Czech Republic), Petr ZVOLSKÝ (203 Czech Republic) and Omar ŠERÝ (203 Czech Republic, guarantor).
Edition Česká a slovenská psychiatrie, Praha, ČLS J.E. Purkyně, 2003, 1212-0383.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/03:00008544
Organization unit Faculty of Science
Keywords in English TaqI A polymorphism; DRD2; alcoholism; alcohol dependence; association
Tags alcohol dependence, alcoholism, association, DRD2, TaqI A polymorphism
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Omar Šerý, Ph.D., učo 18120. Changed: 14/4/2010 13:32.
Abstract
Do studie bylo zahrnuto celekm 571 osob, z toho 280 alkoholiků a 291 kontrolních osob. Pomocí PCR a restrikční analýzy byl určen genotyp. U alkoholiků i kontrol byla zjištěna shodná frekvence alely A1. Nebyl zjištěn vztah TaqI A polymorfizmu genu pro DRD2 k alkoholizmu v populaci České republiky.
Abstract (in English)
In this study 571 persons were included (280 alcoholics and 291 controls). The diagnostic criteria DSM-IV and ICD-10 for the diagnosis of alcoholism were used. The genomic DNA from the blood using the commercial kit UltraClean Blood Spin kit (MoBio, USA) was isolated. PCR and RFLP for genotypisation were used. We found the same frequency of the A1 allele in alcoholics and controls (0,18). Statistically significant difference in the frequency of the A1 allele was observed between males and females in control group (p = 0.038). No association of the TaqI A polymorphism to the alcohol dependence in the Czech Republic was found.
Links
NF5991, research and development projectName: Genetika závislostí: zjišťování vztahu polymorfizmů kandidátních genů k alkoholizmu
Investor: Ministry of Health of the CR, Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.
PrintDisplayed: 28/5/2024 18:44