BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ a Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. Journal of Biological Inorganic Chemistry. Heidelberg: Springer Verlag, 2000, roč. 2000, 5/3, s. 364-368. ISSN 0949-8257. |
Další formáty:
BibTeX
LaTeX
RIS
@article{485464, author = {Brabec, Viktor and Neplechová, Kamila and Kašpárková, Jana and Farrell, Nicholas}, article_location = {Heidelberg}, article_number = {5/3}, keywords = {DNA;cisplatin; transplatin; cross-link; dimethyl sulfate}, language = {eng}, issn = {0949-8257}, journal = {Journal of Biological Inorganic Chemistry}, title = {Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups}, url = {http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm}, volume = {2000}, year = {2000} }
TY - JOUR ID - 485464 AU - Brabec, Viktor - Neplechová, Kamila - Kašpárková, Jana - Farrell, Nicholas PY - 2000 TI - Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups JF - Journal of Biological Inorganic Chemistry VL - 2000 IS - 5/3 SP - 364-368 EP - 364-368 PB - Springer Verlag SN - 09498257 KW - DNA;cisplatin KW - transplatin KW - cross-link KW - dimethyl sulfate UR - http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm N2 - DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug. ER -
BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ a Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. \textit{Journal of Biological Inorganic Chemistry}. Heidelberg: Springer Verlag, 2000, roč.~2000, 5/3, s.~364-368. ISSN~0949-8257.
|