Mixed ligand complexes of platinum(II) and palladium(II) with
cytokinin-derived compounds Bohemine and Olomoucine: X-ray
structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O
{Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpu
rine, Bohemine}

J 2003

Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}

TRÁVNÍČEK, Z., M. MALOŇ, M. ZATLOUKAL, K. DOLEŽAL, M. STRNAD et. al.

Základní údaje

Originální název

Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}

Autoři

TRÁVNÍČEK, Z. (203 Česká republika), M. MALOŇ (203 Česká republika), M. ZATLOUKAL (203 Česká republika), K. DOLEŽAL (203 Česká republika), M. STRNAD (203 Česká republika) a Jaromír MAREK (203 Česká republika, garant)

Vydání

Journal of Inorganic Biochemistry, Amsterdam, Elsevier Science, 2003, 0162-0134

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.343

Kód RIV

RIV/00216224:14310/03:00008013

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

antitumor drug; structure; cytokinin

Štítky

antitumor drug, CYTOKININ, structure

Změněno: 21. 5. 2003 10:14, doc. RNDr. Jaromír Marek, Ph.D.

Anotace

V originále

The new square-planar Pt(II) and Pd(II) complexes with cytokinin-derived compounds Bohemine and Olomoucine, having the formulae [Pt(BohH(+))Cl3].H2O (1), [Pt(Boh)(2)Cl-2].3H(2)O (2), [Pt(Boh-H)Cl(H2O)2].H2O (3), [Pt(OloH(+))Cl-3].H2O (4), [Pd(BohH(+))Cl-3].H2O (5), [Pd(Boh)Cl-2(H2O)] (6), [Pd(Boh-H)Cl(H2O)].EtOH (7) and [Pd(OloH(+))Cl-3].H2O (8), where Boh=6(benzylamino)-2-[(3-(hydroxypropyl)amino]-9-isopropylpurine and Olo=6-(benzylamino)-2-[(2-(hydroxyethyl)amino]-9-methylpurine, have been synthesized. The complexes have been characterized by elemental analyses, IR, FAB+ mass, H-1, C-13 and Pt-195 NMR spectra, and conductivity data. The molecular structure of the complex [Pt(BohH(+)-N7)Cl-3].9/5H(2)O has been determined by an X-ray diffraction study. Results from physical studies show that both Bohemine and Olomoucine are coordinated to transition metals through the N(7) atom of purine ring in all the complexes. The prepared compounds have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines and IC50 values have been also determined for ail the complexes. IC50 values estimated for the Pt(II)-Bohemine complexes (2.1-16 muM) allow us to conclude that they could find utilization in antineoplastic therapy. Thus, from a pharmacological point of view, Pt(II) complexes of Bohemine may represent compounds for a new class of antitumor drugs.

Návaznosti

GA203/00/0152, projekt VaV

Název: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty

Citovat

TRÁVNÍČEK, Z., M. MALOŇ, M. ZATLOUKAL, K. DOLEŽAL, M. STRNAD a Jaromír MAREK. Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}. Journal of Inorganic Biochemistry. Amsterdam: Elsevier Science, 2003, roč. 94, č. 4, s. 307-316. ISSN 0162-0134.

@article{486322,
   author = {Trávníček, Z. and Maloň, M. and Zatloukal, M. and Doležal, K. and Strnad, M. and Marek, Jaromír},
   article_location = {Amsterdam},
   article_number = {4},
   keywords = {antitumor drug; structure; cytokinin},
   language = {eng},
   issn = {0162-0134},
   journal = {Journal of Inorganic Biochemistry},
   title = {Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}},
   volume = {94},
   year = {2003}
}

TY  - JOUR
ID  - 486322
AU  - Trávníček, Z. - Maloň, M. - Zatloukal, M. - Doležal, K. - Strnad, M. - Marek, Jaromír
PY  - 2003
TI  - Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}
JF  - Journal of Inorganic Biochemistry
VL  - 94
IS  - 4
SP  - 307-316
EP  - 307-316
PB  - Elsevier Science
SN  - 01620134
KW  - antitumor drug
KW  - structure
KW  - cytokinin
N2  - The new square-planar Pt(II) and Pd(II) complexes with cytokinin-derived compounds Bohemine and Olomoucine, having the formulae [Pt(BohH(+))Cl3].H2O (1), [Pt(Boh)(2)Cl-2].3H(2)O (2), [Pt(Boh-H)Cl(H2O)2].H2O (3), [Pt(OloH(+))Cl-3].H2O (4), [Pd(BohH(+))Cl-3].H2O (5), [Pd(Boh)Cl-2(H2O)] (6), [Pd(Boh-H)Cl(H2O)].EtOH (7) and [Pd(OloH(+))Cl-3].H2O (8), where Boh=6(benzylamino)-2-[(3-(hydroxypropyl)amino]-9-isopropylpurine and Olo=6-(benzylamino)-2-[(2-(hydroxyethyl)amino]-9-methylpurine, have been synthesized. The complexes have been characterized by elemental analyses, IR, FAB+ mass, H-1, C-13 and Pt-195 NMR spectra, and conductivity data. The molecular structure of the complex [Pt(BohH(+)-N7)Cl-3].9/5H(2)O has been determined by an X-ray diffraction study. Results from physical studies show that both Bohemine and Olomoucine are coordinated to transition metals through the N(7) atom of purine ring in all the complexes. The prepared compounds have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines and IC50 values have been also determined for ail the complexes. IC50 values estimated for the Pt(II)-Bohemine complexes (2.1-16 muM) allow us to conclude that they could find utilization in antineoplastic therapy. Thus, from a pharmacological point of view, Pt(II) complexes of Bohemine may represent compounds for a new class of antitumor drugs.
ER  -

TRÁVNÍČEK, Z., M. MALOŇ, M. ZATLOUKAL, K. DOLEŽAL, M. STRNAD a Jaromír MAREK. Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O $\{$Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine$\}$. \textit{Journal of Inorganic Biochemistry}. Amsterdam: Elsevier Science, 2003, roč.~94, č.~4, s.~307-316. ISSN~0162-0134.

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