Detailed Information on Publication Record
2003
Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}
TRÁVNÍČEK, Z., M. MALOŇ, M. ZATLOUKAL, K. DOLEŽAL, M. STRNAD et. al.Basic information
Original name
Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH(+)-N7)Cl-3].9/5H(2)O {Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine}
Authors
TRÁVNÍČEK, Z. (203 Czech Republic), M. MALOŇ (203 Czech Republic), M. ZATLOUKAL (203 Czech Republic), K. DOLEŽAL (203 Czech Republic), M. STRNAD (203 Czech Republic) and Jaromír MAREK (203 Czech Republic, guarantor)
Edition
Journal of Inorganic Biochemistry, Amsterdam, Elsevier Science, 2003, 0162-0134
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10402 Inorganic and nuclear chemistry
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.343
RIV identification code
RIV/00216224:14310/03:00008013
Organization unit
Faculty of Science
Keywords in English
antitumor drug; structure; cytokinin
Tags
Změněno: 21/5/2003 10:14, doc. RNDr. Jaromír Marek, Ph.D.
Abstract
V originále
The new square-planar Pt(II) and Pd(II) complexes with cytokinin-derived compounds Bohemine and Olomoucine, having the formulae [Pt(BohH(+))Cl3].H2O (1), [Pt(Boh)(2)Cl-2].3H(2)O (2), [Pt(Boh-H)Cl(H2O)2].H2O (3), [Pt(OloH(+))Cl-3].H2O (4), [Pd(BohH(+))Cl-3].H2O (5), [Pd(Boh)Cl-2(H2O)] (6), [Pd(Boh-H)Cl(H2O)].EtOH (7) and [Pd(OloH(+))Cl-3].H2O (8), where Boh=6(benzylamino)-2-[(3-(hydroxypropyl)amino]-9-isopropylpurine and Olo=6-(benzylamino)-2-[(2-(hydroxyethyl)amino]-9-methylpurine, have been synthesized. The complexes have been characterized by elemental analyses, IR, FAB+ mass, H-1, C-13 and Pt-195 NMR spectra, and conductivity data. The molecular structure of the complex [Pt(BohH(+)-N7)Cl-3].9/5H(2)O has been determined by an X-ray diffraction study. Results from physical studies show that both Bohemine and Olomoucine are coordinated to transition metals through the N(7) atom of purine ring in all the complexes. The prepared compounds have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines and IC50 values have been also determined for ail the complexes. IC50 values estimated for the Pt(II)-Bohemine complexes (2.1-16 muM) allow us to conclude that they could find utilization in antineoplastic therapy. Thus, from a pharmacological point of view, Pt(II) complexes of Bohemine may represent compounds for a new class of antitumor drugs.
Links
| GA203/00/0152, research and development project |
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