Další formáty:
BibTeX
LaTeX
RIS
@inproceedings{487443, author = {Kaňková, Kateřina and Márová, Ivana and Stejskalová, Andrea}, address = {London, Great Britain}, booktitle = {Stress, Signalling and Control}, keywords = {diabetes mellitus; complications; polymorphism; antioxidant}, language = {eng}, location = {London, Great Britain}, pages = {59-59}, publisher = {Biochemical Society}, title = {Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications}, year = {2003} }
TY - JOUR ID - 487443 AU - Kaňková, Kateřina - Márová, Ivana - Stejskalová, Andrea PY - 2003 TI - Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications PB - Biochemical Society CY - London, Great Britain KW - diabetes mellitus KW - complications KW - polymorphism KW - antioxidant N2 - Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patients with type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manifestation was proved irrespective of diabetes (P=0.018 and 0.021, respectively). Frequencies of A111E GLY1 and M55L PON haplotypes were significantly different between DAMD/MD and non- DAMD/MD groups (P=0.016). Conclusions: Polymorphisms in genes encoding antioxidant enzymes could belong to cluster of genetic susceptibility risk factors for diabetic complications. ER -
KAŇKOVÁ, Kateřina, Ivana MÁROVÁ a Andrea STEJSKALOVÁ. Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications. In \textit{Stress, Signalling and Control}. London, Great Britain: Biochemical Society, 2003, s.~59.
|