ŠERÝ, Omar, Renáta HLADILOVÁ, Miroslav NOVOTNÝ, Hana HŘÍBKOVÁ, Vladimír ZNOJIL a Petr ZVOLSKÝ. Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism. Acta Neuropsychiatrica. Blackwell Munksgaard, 2003, roč. 15, č. 5, s. 257-261. ISSN 0924-2708. |
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@article{488103, author = {Šerý, Omar and Hladilová, Renáta and Novotný, Miroslav and Hříbková, Hana and Znojil, Vladimír and Zvolský, Petr}, article_number = {5}, keywords = {IL-6; cytokine; alcohol dependence; polymorphism; association}, language = {eng}, issn = {0924-2708}, journal = {Acta Neuropsychiatrica}, title = {Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism}, volume = {15}, year = {2003} }
TY - JOUR ID - 488103 AU - Šerý, Omar - Hladilová, Renáta - Novotný, Miroslav - Hříbková, Hana - Znojil, Vladimír - Zvolský, Petr PY - 2003 TI - Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism JF - Acta Neuropsychiatrica VL - 15 IS - 5 SP - 257-261 EP - 257-261 PB - Blackwell Munksgaard SN - 09242708 KW - IL-6 KW - cytokine KW - alcohol dependence KW - polymorphism KW - association N2 - Objectives: IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. The aim of the present association study was to examine the effect of G/C -174 polymorphism of IL-6 gene on dispositions to the alcoholism. Methods: We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. Results: The significant difference in G allele frequency between alcoholic group (0,52) and control group (0,59) was found (p<0,03). Conclusion: To our knowledge, this is the first finding providing evidence for an association between alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between IL-6 gene and alcoholism is discussed. ER -
ŠERÝ, Omar, Renáta HLADILOVÁ, Miroslav NOVOTNÝ, Hana HŘÍBKOVÁ, Vladimír ZNOJIL a Petr ZVOLSKÝ. Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism. \textit{Acta Neuropsychiatrica}. Blackwell Munksgaard, 2003, roč.~15, č.~5, s.~257-261. ISSN~0924-2708.
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