Dynamics of CYP2D6 activity and clinical response to
paroxetine, alprazolam and their combination in patients with
depressive disorder

J 2003

Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL a Barbora RAVČUKOVÁ

Základní údaje

Originální název

Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

Autoři

HADAŠOVÁ, Eva (203 Česká republika, garant), Alexandra ŽOURKOVÁ (203 Česká republika), Josef TOMANDL (203 Česká republika) a Barbora RAVČUKOVÁ (203 Česká republika)

Vydání

Chemické listy, Praha, Česká spol. chemická, 2003, 0009-2770

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.345

Kód RIV

RIV/00216224:14110/03:00008962

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients

Štítky

alprazolam, CYP2D6, genetic polymorphism, paroxetine, psychiatric patients

Změněno: 14. 10. 2003 12:07, prof. MUDr. Eva McCaskey Hadašová, CSc.

Anotace

V originále

Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.

Citovat

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL a Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. Chemické listy. Praha: Česká spol. chemická, 2003, roč. 97 (S), červen, s. S180, 1 s. ISSN 0009-2770.

@article{489426,
   author = {Hadašová, Eva and Žourková, Alexandra and Tomandl, Josef and Ravčuková, Barbora},
   article_location = {Praha},
   article_number = {červen},
   keywords = {Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients},
   language = {eng},
   issn = {0009-2770},
   journal = {Chemické listy},
   note = {Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003},
   title = {Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder},
   volume = {97 (S)},
   year = {2003}
}

TY  - JOUR
ID  - 489426
AU  - Hadašová, Eva - Žourková, Alexandra - Tomandl, Josef - Ravčuková, Barbora
PY  - 2003
TI  - Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder
JF  - Chemické listy
VL  - 97 (S)
IS  - červen
SP  - S180
EP  - S180
PB  - Česká spol. chemická
SN  - 00092770
N1  - Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003
KW  - Genetic polymorphism
KW  - CYP2D6
KW  - paroxetine
KW  - alprazolam
KW  - psychiatric patients
N2  - Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.
ER  -

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL a Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. \textit{Chemické listy}. Praha: Česká spol. chemická, 2003, roč.~97 (S), červen, s.~S180, 1 s. ISSN~0009-2770.

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