LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour. Behavioural Pharmacology. London, UK: Lippincott Williams & Wilkins, 2003, vol. 14, Suppl. 1, p. 60 - 60. ISSN 0955-8810.
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Basic information
Original name Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
Authors LANDA, Leoš (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic, guarantor) and Karel ŠLAIS (203 Czech Republic).
Edition Behavioural Pharmacology, London, UK, Lippincott Williams & Wilkins, 2003, 0955-8810.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.375
RIV identification code RIV/00216224:14110/03:00008969
Organization unit Faculty of Medicine
Keywords in English Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice
Tags AM 251, behavioural sensitization, locomotion, methamphetamine, methanandamide, mice
Tags International impact
Changed by Changed by: doc. Mgr. MVDr. Leoš Landa, Ph.D., učo 70449. Changed: 30/11/2006 13:23.
Abstract
In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-treated with methamphetamine a significant behavioural sensitization was present the mice pre-treated with the combination of methamphetamine and AM 251 responded with significantly lower metamphetamine behavioural effect when compared to just methamphetamine sensitized animals.
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