LANDA, Leoš, Karel ŠLAIS a Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. European Neuropsychopharmacology. Amsterdam: Elsevier, 2003, roč. 13, Suppl. 4, s. 416 - 417. ISSN 0924-977X. |
Další formáty:
BibTeX
LaTeX
RIS
@article{489443, author = {Landa, Leoš and Šlais, Karel and Šulcová, Alexandra}, article_location = {Amsterdam}, article_number = {Suppl. 4}, keywords = {AM 251; behavioral sensitization; locomotor/exploratory activity; mice}, language = {eng}, issn = {0924-977X}, journal = {European Neuropsychopharmacology}, title = {Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice}, volume = {13}, year = {2003} }
TY - JOUR ID - 489443 AU - Landa, Leoš - Šlais, Karel - Šulcová, Alexandra PY - 2003 TI - Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice JF - European Neuropsychopharmacology VL - 13 IS - Suppl. 4 SP - 416 - 417 EP - 416 - 417 PB - Elsevier SN - 0924977X KW - AM 251 KW - behavioral sensitization KW - locomotor/exploratory activity KW - mice N2 - Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the group pre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were significantly lower compared to methamphetamine sensitized animals. ER -
LANDA, Leoš, Karel ŠLAIS a Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier, 2003, roč.~13, Suppl. 4, s.~416 - 417. ISSN~0924-977X.
|