Inhibition of cannabinoid CB1 receptor attenuates behavioural
sensitization to methamphetamine in mice

J 2003

Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

LANDA, Leoš, Karel ŠLAIS a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Autoři

LANDA, Leoš (203 Česká republika), Karel ŠLAIS (203 Česká republika) a Alexandra ŠULCOVÁ (203 Česká republika, garant)

Vydání

European Neuropsychopharmacology, Amsterdam, Elsevier, 2003, 0924-977X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.842

Kód RIV

RIV/00216224:14110/03:00008970

Organizační jednotka

Lékařská fakulta

UT WoS

000185412300676

Klíčová slova anglicky

AM 251; behavioral sensitization; locomotor/exploratory activity; mice

Štítky

AM 251, behavioral sensitization, locomotor/exploratory activity, mice

Příznaky

Mezinárodní význam

Změněno: 30. 11. 2006 13:23, doc. Mgr. MVDr. Leoš Landa, Ph.D.

Anotace

V originále

Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the group pre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were significantly lower compared to methamphetamine sensitized animals.

Citovat

LANDA, Leoš, Karel ŠLAIS a Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. European Neuropsychopharmacology. Amsterdam: Elsevier, 2003, roč. 13, Suppl. 4, s. 416 - 417. ISSN 0924-977X.

@article{489443,
   author = {Landa, Leoš and Šlais, Karel and Šulcová, Alexandra},
   article_location = {Amsterdam},
   article_number = {Suppl. 4},
   keywords = {AM 251; behavioral sensitization; locomotor/exploratory activity; mice},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice},
   volume = {13},
   year = {2003}
}

TY  - JOUR
ID  - 489443
AU  - Landa, Leoš - Šlais, Karel - Šulcová, Alexandra
PY  - 2003
TI  - Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice
JF  - European Neuropsychopharmacology
VL  - 13
IS  - Suppl. 4
SP  - 416 - 417
EP  - 416 - 417
PB  - Elsevier
SN  - 0924977X
KW  - AM 251
KW  - behavioral sensitization
KW  - locomotor/exploratory activity
KW  - mice
N2  - Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the group pre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were significantly lower compared to methamphetamine sensitized animals.
ER  -

LANDA, Leoš, Karel ŠLAIS a Alexandra ŠULCOVÁ. Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier, 2003, roč.~13, Suppl. 4, s.~416 - 417. ISSN~0924-977X.

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