IZAKOVIČOVÁ HOLLÁ, Lydie, Marcel SCHÜLLER, Dana BUČKOVÁ and Jiří VÁCHA. Neuronal nitric oxide synthase (NOS1) gene polymorphism and IgE-mediated allergy in the Central European population. Allergy. Denmark: Munksgaard International Publishers, 2004, vol. 59, No 5, p. 548-552. ISSN 0105-4538.
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Basic information
Original name Neuronal nitric oxide synthase (NOS1) gene polymorphism and IgE-mediated allergy in the Central European population
Name in Czech Polymorfizmus v genu pro neuronální syntázu oxidu dusnatéhé (NOS1) a IgE-zprostředkované alergie ve středoevropské populaci
Authors IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Marcel SCHÜLLER (203 Czech Republic), Dana BUČKOVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Allergy, Denmark, Munksgaard International Publishers, 2004, 0105-4538.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Denmark
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.496
RIV identification code RIV/00216224:14110/04:00009874
Organization unit Faculty of Medicine
UT WoS 000220703200013
Keywords in English IgE; gene; polymorphism; allergy; NOS; nitric oxide
Tags allergy, gene, IgE, nitric oxide, NOS, polymorphism
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 11:53.
Abstract
Several findings suggest that nitric oxide (NO) plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of allergic diseases. Our study investigates a possible association of C/T transition located 276-bp downstream from the translation termination site in exon 29 of the human NOS1 gene with IgE-mediated allergic diseases in the Czech population.
Abstract (in Czech)
Řada nálezů naznačuje, že oxid dusnatý (NO) hraje významnou úlohu v regulaci Th1/Th2 rovnováhy a podílí se na rozvoji alergických nemocí. Naše práce zkoumá možnou asociaci C/T záměny lokalizované 276-bp od místa ukončení translace v exonu 29 genu pro NOS1 s IgE-zprostředkovanými alergickými chorobami v české populaci
Links
GP310/03/P045, research and development projectName: Analýza polymorfizmů v genech pro syntetázu oxidu dusnatého (NOS) u atopického astmatu a jiných alergií v české populaci
Investor: Czech Science Foundation
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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