2003
Pozdní následky léčby antracyklinem na funkci levé srdeční komory po léčbě nádoru v dětském věku
ELBL, Lubomír; Hana HRSTKOVÁ and Václav CHALOUPKABasic information
Original name
Pozdní následky léčby antracyklinem na funkci levé srdeční komory po léčbě nádoru v dětském věku
Name (in English)
The late consequences of anthracycline treatment on left ventricular function after treatment for childhood cancer
Authors
ELBL, Lubomír (203 Czech Republic, guarantor); Hana HRSTKOVÁ (203 Czech Republic) and Václav CHALOUPKA (203 Czech Republic)
Edition
European Journal of Pediatrics, 2003
Other information
Language
Czech
Type of outcome
Article in a journal
Field of Study
30209 Paediatrics
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
RIV identification code
RIV/00216224:14330/03:00012151
Organization unit
Faculty of Informatics
UT WoS
000185228800007
Keywords in English
Anthracyclines. Childhood malignancy.Echocardiography.Late cardiotoxicity
Changed: 2/6/2005 15:08, RNDr. JUDr. Vladimír Šmíd, CSc.
In the original language
Pozdní následky léčby antracyklinem na funkci levé srdeční komory po léčbě nádoru v dětském věku.
In English
The purpose of this study was to determine the incidence of changes in left ventricular function in patients in long-term remission after treatment with anthracyclines for a childhood malignancy. The authors examined 155 patients in disease remission who underwent treatment protocols utilising antthacyclines in childhood. The group comprised 90 males and 65 females aged 15+-4,9 years, median 15 years).The age at the time of diagnosis and start of treatment was 8,6+-4,9 years (range 1-18 years, median 8 years). The time of follow-up was 7,3 +-4 years (range 1-21 years, median 6,3 years). The patients were given a cumulative dose of doxorubicin or daunorubicin of 250+-131 mg/m2 (range 50-1200 mg/m2, median 240 mg/m2). The values of ejection fraction below 55% and fractional shortening below 30% assessed by means of echocardiography were considered as pathological. The control group consisted of 41 volunteers. The control group consisted of 41 volunteers. Pathological values of fractional shortenintg were found in 12 patients (8%). Only one patient (0,64%) showed the development of heart failure due to cardiomyopathy. The group of the patients after chemotherapy revealed significantly worse values of left ventricular endsystolic wall stress, mean velocity of circumferential fibre shortening, Tei index, and isovolumic relaxation period in comparison with the control group. We dound a correlation between the given cumulative dose of anthracyclines and indicators of systolic function of the left ventricle, but not a relation to the time indicators (age at diagnosis, time of follow-up).
Links
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