CIOCCI, Gianluca, Edward MITCHELL, Catherine GAUIER, Michaela WIMMEROVÁ, Dvora SUDAKEVITZ, Serge PÉREZ, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa. FEBS Letters. Amsterdam: Elsevier, 2003, roč. 552, č. 2, s. 297-301. ISSN 0014-5793. |
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@article{490424, author = {Ciocci, Gianluca and Mitchell, Edward and Gauier, Catherine and Wimmerová, Michaela and Sudakevitz, Dvora and Pérez, Serge and GilboaandGarber, Nechama and Imberty, Anne}, article_location = {Amsterdam}, article_number = {2}, keywords = {pseudomonas aeruginosa; cystic fibrosis; lectin; crystal structure}, language = {eng}, issn = {0014-5793}, journal = {FEBS Letters}, title = {Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa}, volume = {552}, year = {2003} }
TY - JOUR ID - 490424 AU - Ciocci, Gianluca - Mitchell, Edward - Gauier, Catherine - Wimmerová, Michaela - Sudakevitz, Dvora - Pérez, Serge - Gilboa-Garber, Nechama - Imberty, Anne PY - 2003 TI - Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa JF - FEBS Letters VL - 552 IS - 2 SP - 297-301 EP - 297-301 PB - Elsevier SN - 00145793 KW - pseudomonas aeruginosa KW - cystic fibrosis KW - lectin KW - crystal structure N2 - The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 Å esolution, and the native protein was solved at 2.4 Å resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the coordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent to that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds. ER -
CIOCCI, Gianluca, Edward MITCHELL, Catherine GAUIER, Michaela WIMMEROVÁ, Dvora SUDAKEVITZ, Serge PÉREZ, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa. \textit{FEBS Letters}. Amsterdam: Elsevier, 2003, roč.~552, č.~2, s.~297-301. ISSN~0014-5793.
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