Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats

NOVÁKOVÁ, Jana. Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats. In Abstract Book of Sixth IBRO World Congress of Neuroscience. Prague (Czech Republic): Neuveden, 2003, s. 205-205. ISBN 80-239-0887-1.

Základní údaje

Originální název

Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats

Autoři

NOVÁKOVÁ, Jana (203 Česká republika, garant)

Vydání

Prague (Czech Republic), Abstract Book of Sixth IBRO World Congress of Neuroscience, od s. 205-205, 1 s. 2003

Nakladatel

Neuveden

---

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/03:00009236

Organizační jednotka

Lékařská fakulta

ISBN

80-239-0887-1

Klíčová slova anglicky

5-HT2 receptor subtype; alpha-methyl-serotonin; methamphetamine; i.v. self-administration; rats

Štítky

5-HT2 receptor subtype, alpha-methyl-serotonin, i.v. self-administration, methamphetamine, rats

---

Anotace

V originále

In the present study, modulation of the reinforcing effects of methamphetamine by the non-selective 5-HT2 receptor agonist alpha-methyl-serotonin was ascertained using the method of i.v. self-administration in rats. In summary, our findings suggest that 5-HT2 receptor activation might attenuate methamphetamine self-administration. These results are in accordance with the findings of Munzar et al. (1999) indicating that 5-HT mediation of discriminative stimulus actions of methamphetamine appears to be involved to a big extent in stimulation at 5-HT2A/2C receptors.