DOSTÁLEK, Miroslav, Jiří SLÍVA, Eva HADAŠOVÁ and Josef TOMANDL. Combined treatment with methamphetamine and fluoxetine influences pharmacokinetic behaviour of dextromethorphane in the rat. Psychiatrie. Praha: Tigis s.r.o., 2003, vol. 7, suppl 1, p. 16-16. ISSN 1211-7579.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Combined treatment with methamphetamine and fluoxetine influences pharmacokinetic behaviour of dextromethorphane in the rat
Name in Czech Vliv fluoxetinu na biotransformacní procesy metamfetaminu
Authors DOSTÁLEK, Miroslav (203 Czech Republic), Jiří SLÍVA (203 Czech Republic), Eva HADAŠOVÁ (203 Czech Republic, guarantor) and Josef TOMANDL (203 Czech Republic).
Edition Psychiatrie, Praha, Tigis s.r.o. 2003, 1211-7579.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/03:00009239
Organization unit Faculty of Medicine
Keywords in English methamphetamine; pharmacokinetics; dextromethorphan
Tags dextromethorphan, methamphetamine, pharmacokinetics
Changed by Changed by: PharmDr. Miroslav Dostálek, Ph.D., učo 63560. Changed: 31/5/2005 10:38.
Abstract
The purpose of this study was to assess pharmacokinetics of dextromethorphane (model substrate of CYP2D2). The results suggest that fluoxetine therapy in methamphetamine dependece could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of drug.
Abstract (in Czech)
The purpose of this study was to assess pharmacokinetics of dextromethorphane (model substrate of CYP2D2). The results suggest that fluoxetine therapy in methamphetamine dependece could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of drug.
PrintDisplayed: 21/5/2024 20:39