Rescue of rat spinal motoneurons from avulsion-induced cell
death by intrathecal administration of IGF-I and Cerebrolysin.

J 2003

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA a Lubomír STEJSKAL

Základní údaje

Originální název

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

Název česky

Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů

Autoři

HANINEC, Pavel (203 Česká republika), Petr DUBOVÝ (203 Česká republika, garant), Ladislav HOUŠŤAVA (203 Česká republika) a Lubomír STEJSKAL (203 Česká republika)

Vydání

Annals of Anatomy, Jena, Urban&Fischer Verlag, 2003, 0940-9602

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.500

Kód RIV

RIV/00216224:14110/03:00009288

Organizační jednotka

Lékařská fakulta

UT WoS

000183351200007

Klíčová slova anglicky

motoneuron; promotion; neurotrophic

Štítky

motoneuron, neurotrophic, Promotion

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 10:55, prof. RNDr. Petr Dubový, CSc.

Anotace

ORIG CZ

V originále

The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.

Česky

Avuilse ventrálního kořene spinálního nervu způsobuje ztrátu motoneuronů

Návaznosti

NF6658, projekt VaV

Název: Alternativní přístupy v rekonstrukci pažní pleteně a experimentální vyhodnocení účinku neurotrofinů na přímou a kolaterální reinervaci

Investor: Ministerstvo zdravotnictví ČR, Alternativní přístupy v rekonstrukci pažní pleteně a experimentální vyhodnocení účinku neurotrofinů na přímou a kolaterální reinervaci

Citovat

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA a Lubomír STEJSKAL. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Annals of Anatomy. Jena: Urban&Fischer Verlag, 2003, roč. 185, č. 3, s. 233-238. ISSN 0940-9602.

@article{491118,
   author = {Haninec, Pavel and Dubový, Petr and Houšťava, Ladislav and Stejskal, Lubomír},
   article_location = {Jena},
   article_number = {3},
   keywords = {motoneuron; promotion; neurotrophic},
   language = {eng},
   issn = {0940-9602},
   journal = {Annals of Anatomy},
   title = {Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.},
   volume = {185},
   year = {2003}
}

TY  - JOUR
ID  - 491118
AU  - Haninec, Pavel - Dubový, Petr - Houšťava, Ladislav - Stejskal, Lubomír
PY  - 2003
TI  - Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.
JF  - Annals of Anatomy
VL  - 185
IS  - 3
SP  - 233
EP  - 233
PB  - Urban&Fischer Verlag
SN  - 09409602
KW  - motoneuron
KW  - promotion
KW  - neurotrophic
N2  - The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.
ER  -

HANINEC, Pavel, Petr DUBOVÝ, Ladislav HOUŠŤAVA a Lubomír STEJSKAL. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. \textit{Annals of Anatomy}. Jena: Urban\&{}Fischer Verlag, 2003, roč.~185, č.~3, s.~233-238. ISSN~0940-9602.

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