LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. Cross-sensitization with morphine to methamphetamine effects on locomotion in mice. Psychiatrie. Praha: Tigis s.r.o., 2004, vol. 8, Suppl. 1, p. 53-53. ISSN 1211-7579.
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Basic information
Original name Cross-sensitization with morphine to methamphetamine effects on locomotion in mice
Name in Czech Zkřížená sensitizace morfinem k účinkům metamfetaminu na lokomoci u myší
Authors LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic).
Edition Psychiatrie, Praha, Tigis s.r.o. 2004, 1211-7579.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00009922
Organization unit Faculty of Medicine
Keywords in English behavioural sensitization; methamphetamine; morphine; locomotor activity; mice
Tags behavioural sensitization, locomotor activity, methamphetamine, mice, morphine
Changed by Changed by: prof. MUDr. Alexandra Šulcová, CSc., učo 1937. Changed: 16/5/2005 10:52.
Abstract
This study was aimed on development of cross-sensitization with morphine (MO) to methamphetamine (MET). Behavioural responses were measured in the "open field" test. Mice in two groups were pretreated for seven days either with MO at the dose 10 mg/kg/day or with MET at the dose of 2,5 mg/kg/day. On the day 8 all mice were given the "challenge dose" of MET 2.5 mg/kg to evaluate if a cross-sensitization developed. It has been shown that behavioural sensitization was present in both the group pretreated with MET and also in the group pretreated with MO.
Abstract (in Czech)
Byla potrvzena zkřížená sensitizace k účinkům metamfetaminu na lokomoci u myší předchcyz aplikací morfinu
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