TRANTÍREK, Lukáš, Erik CAHA and Radovan FIALA. NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids. In Materials Structure. 1st ed. Prague: Czech and Slovak Crystalographic Association, 2003, p. 40-41. ISBN 1211-5894.
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Basic information
Original name NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids
Authors TRANTÍREK, Lukáš (203 Czech Republic), Erik CAHA (203 Czech Republic) and Radovan FIALA (203 Czech Republic, guarantor).
Edition 1. vyd. Prague, Materials Structure, p. 40-41, 2 pp. 2003.
Publisher Czech and Slovak Crystalographic Association
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10403 Physical chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/03:00009533
Organization unit Faculty of Science
ISBN 1211-5894
Keywords in English RNA; dynamics; NMR; spectroscopy; relaxation; molecular dynamics
Tags dynamics, molecular dynamics, NMR, relaxation, RNA, spectroscopy
Changed by Changed by: doc. RNDr. Radovan Fiala, CSc., učo 564. Changed: 23/2/2004 15:21.
Abstract
Internal motions of two 14-nt RNA hairpins containing UUCG and GCAA tetraloops were studied by C-13 NMR relaxation and molecular dynamics. While both tetraloops exhibit an increased mobility on the fast time scale, with the GCAA loop we have detected a significant contribution of conformational dynamics on the millisecond to microsecond time scale. This is consistent with the observation that the GNRA family of tetraloops appears more flexible and tolerant of the conformational changes important for molecular recognition.
Links
LN00A016, research and development projectName: BIOMOLEKULÁRNÍ CENTRUM
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular Center
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