Další formáty:
BibTeX
LaTeX
RIS
@inproceedings{554261, author = {Nemajerová, Alice and Šmarda, Jan and Zatloukalová, Jiřina and Šmardová, Jana}, address = {Brno}, booktitle = {Memory in Living Systems}, keywords = {CBP; p300; Myb; histone acetylation}, language = {cze}, location = {Brno}, isbn = {80-210-3264-2}, pages = {66-66}, publisher = {Czechoslovak Biological Society}, title = {Differential effects of transcription coactivators CBP and p300 on v-myb-transfromed monoblasts}, year = {2003} }
TY - JOUR ID - 554261 AU - Nemajerová, Alice - Šmarda, Jan - Zatloukalová, Jiřina - Šmardová, Jana PY - 2003 TI - Differential effects of transcription coactivators CBP and p300 on v-myb-transfromed monoblasts PB - Czechoslovak Biological Society CY - Brno SN - 8021032642 KW - CBP KW - p300 KW - Myb KW - histone acetylation N2 - The v-myb oncogene is efficiently expressed in BM2 monoblasts thus blocking their terminal differentiation steps. Histone acetylation plays an important role in regulation of transcription and is particularly relevant to regulation and pathology of hematopoiesis. Recently, we have shown that inhibitor of histone deacetylases trichostatin A (TSA) causes histone hyperacetylation and differentiation of BM2 cells into macrophage polycaryons. In this work we used another approach to stimulate histone acetylation in BM2 cells. We prepared two variants of BM2 cells ectopically expressing two histone acetyl transferases CBP and p300. The expression of CBP as well as p300 itself did not affect the phenotype of BM2 cells, but it enhanced their response to the differentiation inducers TPA and TSA. Although CBP and p300 are closely related proteins, many differences in their function have been described. We noted differences in kinetics of differentiation induced by CBP and p300 in BM2 cells. ER -
NEMAJEROVÁ, Alice, Jan ŠMARDA, Jiřina ZATLOUKALOVÁ a Jana ŠMARDOVÁ. Differential effects of transcription coactivators CBP and p300 on v-myb-transfromed monoblasts. In \textit{Memory in Living Systems}. Brno: Czechoslovak Biological Society, 2003, s.~66. ISBN~80-210-3264-2.
|