Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

ZAHRADNÍČKOVÁ, Eva, Sabina ŠEVČÍKOVÁ, Karel SOUČEK a Jan ŠMARDA. Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts. In Memory in Living Systems. Brno: Czechoslovak Biological Society, 2003, s. 73. ISBN 80-210-3264-2.

Základní údaje

Originální název

Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

Název anglicky

Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

Autoři

ZAHRADNÍČKOVÁ, Eva (203 Česká republika), Sabina ŠEVČÍKOVÁ (203 Česká republika), Karel SOUČEK (203 Česká republika) a Jan ŠMARDA (203 Česká republika, garant)

Vydání

Brno, Memory in Living Systems, s. 73-73, 2003

Nakladatel

Czechoslovak Biological Society

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Další údaje

Jazyk

čeština

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14330/03:00008669

Organizační jednotka

Fakulta informatiky

ISBN

80-210-3264-2

Klíčová slova anglicky

Fos; Myb; proliferation; differentiation; apoptosis

Štítky

apoptosis, differentiation, Fos, Myb, proliferation

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Anotace

V originále

c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.

Anglicky

c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.

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Návaznosti

GA301/01/0040, projekt VaV	Název: Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou Investor: Grantová agentura ČR, Úloha proteinů Fos a Jun v monocytické diferenciaci stimulované kyselinou retinovou
GA301/03/1055, projekt VaV	Název: Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky Investor: Grantová agentura ČR, Studium molekulárních mechanismů způsobujících supresi v-Myb s využitím přístupů proteomiky