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@inproceedings{554262, author = {Zahradníčková, Eva and Ševčíková, Sabina and Souček, Karel and Šmarda, Jan}, address = {Brno}, booktitle = {Memory in Living Systems}, keywords = {Fos; Myb; proliferation; differentiation; apoptosis}, language = {cze}, location = {Brno}, isbn = {80-210-3264-2}, pages = {73-73}, publisher = {Czechoslovak Biological Society}, title = {Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts}, year = {2003} }
TY - JOUR ID - 554262 AU - Zahradníčková, Eva - Ševčíková, Sabina - Souček, Karel - Šmarda, Jan PY - 2003 TI - Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts PB - Czechoslovak Biological Society CY - Brno SN - 8021032642 KW - Fos KW - Myb KW - proliferation KW - differentiation KW - apoptosis N2 - c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell. ER -
ZAHRADNÍČKOVÁ, Eva, Sabina ŠEVČÍKOVÁ, Karel SOUČEK a Jan ŠMARDA. Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts. In \textit{Memory in Living Systems}. Brno: Czechoslovak Biological Society, 2003, s.~73. ISBN~80-210-3264-2.
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