A quantitative model of the cardiac ventricular cell
incorporating the transverse-axial tubular system

J 2003

A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA

Základní údaje

Originální název

A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system

Autoři

PÁSEK, Michal (203 Česká republika, garant), Georges CHRISTÉ (250 Francie) a Jiří ŠIMURDA (203 Česká republika)

Vydání

General Physiology and Biophysics, R&D print, Bratislava, 2003, 0231-5882

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.794

Kód RIV

RIV/00216224:14110/03:00008675

Organizační jednotka

Lékařská fakulta

UT WoS

000187507900006

Klíčová slova anglicky

cardiac cell; tubular system; quantitative modelling

Štítky

Cardiac cell, Quantitative modelling, tubular system

Změněno: 25. 6. 2009 16:16, doc. Ing. Michal Pásek, Ph.D.

Anotace

V originále

The role of the transverse-axial tubular system (TATS) in electrical activity of cardiac cells has not been investigated quantitatively. In this study a mathematical model including the TATS and differential distribution of ionic transfer mechanisms in peripheral and tubular membranes was described. A model of ventricular cardiac cell described by Jafri et al. (1998) was adopted and slightly modified to describe ionic currents and Ca2+ handling. Changes of concentrations in the lumen of the TATS were computed from the total of transmembrane ionic fluxes and ionic exchanges with the pericellular medium. Long-term stability of the model was attained at rest and under regular stimulation. Depletion of Ca2+ by 12.8 % and accumulation of K+ by 4.7 % occurred in the TATS-lumen at physiological conditions and at a stimulation frequency of 1 Hz. The changes were transient and subsided on repolarization within 800 ms (Ca2+) and 300 ms (K+). Nevertheless, the course of action potentials remained virtually unaltered. Simulations of voltage clamp experiments demonstrated that variations in tubular ionic concentrations were detectable as modulation of the recorded membrane currents.

Návaznosti

AV0Z2076919, záměr

Název: Dynamika tekutin, těles a jejich interakce

GP204/02/D129, projekt VaV

Název: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Investor: Grantová agentura ČR, Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Citovat

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA. A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system. General Physiology and Biophysics. R&D print, Bratislava, 2003, roč. 22, č. 3, s. 355-368. ISSN 0231-5882.

@article{554790,
   author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
   article_number = {3},
   keywords = {cardiac cell; tubular system; quantitative modelling},
   language = {eng},
   issn = {0231-5882},
   journal = {General Physiology and Biophysics},
   title = {A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system},
   volume = {22},
   year = {2003}
}

TY  - JOUR
ID  - 554790
AU  - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY  - 2003
TI  - A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system
JF  - General Physiology and Biophysics
VL  - 22
IS  - 3
SP  - 355-368
EP  - 355-368
PB  - R&D print, Bratislava
SN  - 02315882
KW  - cardiac cell
KW  - tubular system
KW  - quantitative modelling
N2  - The role of the transverse-axial tubular system (TATS) in electrical activity of cardiac cells has not been investigated quantitatively. In this study a mathematical model including the TATS and differential distribution of ionic transfer mechanisms in peripheral and tubular membranes was described. A model of ventricular cardiac cell described by Jafri et al. (1998) was adopted and slightly modified to describe ionic currents and Ca2+ handling. Changes of concentrations in the lumen of the TATS were computed from the total of transmembrane ionic fluxes and ionic exchanges with the pericellular medium. Long-term stability of the model was attained at rest and under regular stimulation. Depletion of Ca2+ by 12.8 % and accumulation of K+ by 4.7 % occurred in the TATS-lumen at physiological conditions and at a stimulation frequency of 1 Hz. The changes were transient and subsided on repolarization within 800 ms (Ca2+) and 300 ms (K+). Nevertheless, the course of action potentials remained virtually unaltered. Simulations of voltage clamp experiments demonstrated that variations in tubular ionic concentrations were detectable as modulation of the recorded membrane currents.
ER  -

PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA. A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system. \textit{General Physiology and Biophysics}. R\&{}D print, Bratislava, 2003, roč.~22, č.~3, s.~355-368. ISSN~0231-5882.

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