Detailed Information on Publication Record
1994
Induction of type III-deiodinase activity in astroglial cells by retinoids
ESFANDIARI, Ali, Claire GAGELIN, Jean-Michel GAVARET, Stanislav PAVELKA, Ana-Maria LENNON et. al.Basic information
Original name
Induction of type III-deiodinase activity in astroglial cells by retinoids
Authors
ESFANDIARI, Ali (364 Islamic Republic of Iran), Claire GAGELIN (250 France), Jean-Michel GAVARET (250 France), Stanislav PAVELKA (203 Czech Republic, guarantor), Ana-Maria LENNON (250 France), Michel PIERRE (250 France) and Francoise COURTIN (250 France)
Edition
Glia [IF=5.096 (1993); SCI #cit.<35>], 1994, 0894-1491
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/94:00011186
Organization unit
Faculty of Science
UT WoS
A1994NU31200005
Keywords in English
Brain; cultured astrocytes; deiodinase; retinoic acid; thyroid hormones
Tags
International impact, Reviewed
Změněno: 4/1/2009 12:19, doc. RNDr. Stanislav Pavelka, CSc.
Abstract
V originále
Thyroid hormones and retinoic acid (RA) are important modulators of growth, development, and differentiation. The effects of retinoids on type III deiodinase (D-III) activity were examined in astroglial cells cultured in a chemically defined medium devoid of hormones and growth factors. Incubation of astroglial cells with 5 micromolar all-trans-RA caused up to 200-fold increase in D-III activity, which reached a plateau after 48 h. All-trans-RA (5 uM) had little or no effect on type II deiodinase, the enzyme which catalyzes the activation of thyroxine to 3,5,3'-triiodothyronine.
Links
| IA51146, research and development project |
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