| KURFURST, P., Jaromír MAREK, J. VANČO and J. CSÖLLEI. (R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate. Acta Crystallographica Section C: Crystal Structure. Chester, UK: International Union of Crystallography, 2004, vol. 60, No 7, p. o494-o495, 2 pp. ISSN 0108-2701. |
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@article{555975,
author = {Kurfurst, P. and Marek, Jaromír and Vančo, J. and Csöllei, J.},
article_location = {Chester, UK},
article_number = {7},
keywords = {crystal structure; antihypertensive drug; heteroarylaminoethanole derivatives},
language = {eng},
issn = {0108-2701},
journal = {Acta Crystallographica Section C: Crystal Structure},
title = {(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate},
volume = {60},
year = {2004}
}
TY - JOUR
ID - 555975
AU - Kurfurst, P. - Marek, Jaromír - Vančo, J. - Csöllei, J.
PY - 2004
TI - (R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate
JF - Acta Crystallographica Section C: Crystal Structure
VL - 60
IS - 7
SP - o494-o495
EP - o494-o495
PB - International Union of Crystallography
SN - 01082701
KW - crystal structure
KW - antihypertensive drug
KW - heteroarylaminoethanole derivatives
N2 - The title compound, C21H24FN2O2+.Cl-.C3H8O, is a potential drug designed as a hybrid compound with antihypertensive, antioxidant and -adrenolytic activity. The cation contains nearly planar benzofuran and fluorophenyl ring systems, as well as a piperazine ring adopting an almost perfect chair conformation. The benzofuran and piperazine moieties are connected by an ethyl chain, the moieties forming a dihedral angle of 163.12 (13)deg. In the crystal structure, ions and propanol solvent molecules are linked via N-HCl and O-HCl bonds into linear (010) chains.
ER -
KURFURST, P., Jaromír MAREK, J. VANČO and J. CSÖLLEI. (R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate. \textit{Acta Crystallographica Section C: Crystal Structure}. Chester, UK: International Union of Crystallography, 2004, vol.~60, No~7, p.~o494-o495, 2 pp. ISSN~0108-2701.
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