Detailed Information on Publication Record
2004
(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate
KURFURST, P., Jaromír MAREK, J. VANČO and J. CSÖLLEIBasic information
Original name
(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate
Name in Czech
Chlorid (R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinia solvatovaný propan-1-olem
Authors
KURFURST, P. (203 Czech Republic), Jaromír MAREK (203 Czech Republic, guarantor), J. VANČO (703 Slovakia) and J. CSÖLLEI (703 Slovakia)
Edition
Acta Crystallographica Section C: Crystal Structure, Chester, UK, International Union of Crystallography, 2004, 0108-2701
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.728
RIV identification code
RIV/00216224:14310/04:00010157
Organization unit
Faculty of Science
UT WoS
000222429900038
Keywords in English
crystal structure; antihypertensive drug; heteroarylaminoethanole derivatives
Změněno: 10/2/2005 17:10, doc. RNDr. Jaromír Marek, Ph.D.
V originále
The title compound, C21H24FN2O2+.Cl-.C3H8O, is a potential drug designed as a hybrid compound with antihypertensive, antioxidant and -adrenolytic activity. The cation contains nearly planar benzofuran and fluorophenyl ring systems, as well as a piperazine ring adopting an almost perfect chair conformation. The benzofuran and piperazine moieties are connected by an ethyl chain, the moieties forming a dihedral angle of 163.12 (13)deg. In the crystal structure, ions and propanol solvent molecules are linked via N-HCl and O-HCl bonds into linear (010) chains.
In Czech
V práci ji diskutována RTG struktura titulní sloučeniny - potenciálního léčiva s antihypertensivními, antioxidantními a beta-adrenolytickými aktivitami.
Links
GA203/02/0436, research and development project |
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MSM 143100008, plan (intention) |
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