SCHÜLLER, Marcel, Šárka ŠEBELOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Dana BUČKOVÁ and Jiří VÁCHA. IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population. In Abstract Book. Stockholm, Sweden: European Academy of Allergology and Clinical Immunology, 2004, p. 130-130. ISBN 3-9808961-3-7.
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Basic information
Original name IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population
Name in Czech Dva polymorfizmy v promotoru genu pro IL-18 a IgE zprostředkovaná alergie v české populaci
Authors SCHÜLLER, Marcel (203 Czech Republic, guarantor), Šárka ŠEBELOVÁ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Dana BUČKOVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Stockholm, Sweden, Abstract Book, p. 130-130, 1 pp. 2004.
Publisher European Academy of Allergology and Clinical Immunology
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30102 Immunology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010166
Organization unit Faculty of Medicine
ISBN 3-9808961-3-7
Keywords in English IL-18; gene; polymorphism; IgE; allergy
Tags allergy, gene, IgE, IL-18, polymorphism
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 20/1/2005 15:06.
Abstract
The IL-18 gene has been suggested a susceptibility gene for allergic diseases for its important role in the balance between Th1 and Th2 immune responses. This was supported by several studies in which associations between some of the IL-18 gene polymorphisms and different atopic phenotypes were reported. In this study, we investigated an association of IgE-mediated allergic diseases in the Czech population and -133C/G single nucleotide polymorphism in the IL-18 gene promoter 2 which was previously associated with high IgE levels and specific sensitization in one study.
Abstract (in Czech)
IL-18 gen byl označen jako možný gen pro alergické nemoci vzhledem k jeho důležité úloze při udržování rovnováhy mezi Th1 a Th2 imunitní odpovědí. Některé práce našly asociaci mezi vybranými polymorfizmy v genu pro IL-18 a různými atopickými fenotypy. V naší práci jsme analyzovali asociaci IgE zprostředkovaných alergických stavů v české populaci s -133C/G jednonukleotidovou záměnou v promotoru genu pro IL_18, která byla v dřívější studii asociována s vyššími hladinami IgE a specifickou senzitizací.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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