The influence of cannabinoid CB2 receptor agonist JWH 015 on
sensitization to methamphetamine in the model of mouse
agonistic behaviour

J 2004

The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

LANDA, Leoš, Alexandra ŠULCOVÁ a Karel ŠLAIS

Základní údaje

Originální název

The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

Název česky

Vliv agonisty kanabinoidního receptoru CB2 JWH015 na rozvoj sensitizace v modelu agonistického chování myší

Autoři

LANDA, Leoš (203 Česká republika, garant), Alexandra ŠULCOVÁ (203 Česká republika) a Karel ŠLAIS (203 Česká republika)

Vydání

Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2004, 0960-7560

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00010239

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

behavioural sensitization;CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice

Štítky

agonistic behaviour, behavioural sensitization, CB2 receptor, JWH-015, methamphetamine, mice

Změněno: 29. 12. 2004 14:33, prof. MUDr. Alexandra Šulcová, CSc.

Anotace

ORIG CZ

V originále

The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.

Česky

Rozvoj behaviorální sensitizace k antiagresivnímu účinku metamfetaminu u myší není vyvolán premedikací agonistou CNB2 kanabinoidních receptorů JWH015.

Citovat

LANDA, Leoš, Alexandra ŠULCOVÁ a Karel ŠLAIS. The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, roč. 43, č. 1, s. 41-42. ISSN 0960-7560.

@article{557234,
   author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel},
   article_location = {Milano, Italy},
   article_number = {1},
   keywords = {behavioural sensitization;CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice},
   language = {eng},
   issn = {0960-7560},
   journal = {Homeostasis in Health and Diseases},
   title = {The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour},
   volume = {43},
   year = {2004}
}

TY  - JOUR
ID  - 557234
AU  - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel
PY  - 2004
TI  - The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
JF  - Homeostasis in Health and Diseases
VL  - 43
IS  - 1
SP  - 41-42
EP  - 41-42
PB  - CIANS Homeostasis
SN  - 09607560
KW  - behavioural sensitization;CB2 receptor
KW  - methamphetamine
KW  - JWH-015
KW  - agonistic behaviour
KW  - mice
N2  - The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.
ER  -

LANDA, Leoš, Alexandra ŠULCOVÁ a Karel ŠLAIS. The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour. \textit{Homeostasis in Health and Diseases}. Milano, Italy: CIANS Homeostasis, 2004, roč.~43, č.~1, s.~41-42. ISSN~0960-7560.

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